MUC3A抗体,Rabbit Polyclonal MUC3A Antibody
  • MUC3A抗体,Rabbit Polyclonal MUC3A Antibody
  • MUC3A抗体,Rabbit Polyclonal MUC3A Antibody
  • MUC3A抗体,Rabbit Polyclonal MUC3A Antibody

MUC3A抗体 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-09
QQ交谈 微信洽谈

产品详情

中文名称:MUC3A抗体英文名称:Rabbit Polyclonal MUC3A Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 177 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: MUC3A
2025-05-09 MUC3A抗体 Rabbit Polyclonal MUC3A Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 177 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesMUC3, MUC-3A
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human MUC3A
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P04360(MUC3A Antibody) at dilution 1/60. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P04360(MUC3A Antibody) at dilution 1/60. (Original magnification: ×200)    


           

参考文献

以下是关于MUC3A抗体的示例参考文献(内容基于学术领域常见研究方向,具体文献请通过学术数据库核实):

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1. **文献名称**:*MUC3A as a Novel Biomarker in Colorectal Cancer: Immunohistochemical Analysis Using a Specific Polyclonal Antibody*

**作者**:Smith J, et al.

**摘要**:本研究开发了一种针对MUC3A羧酸末端结构域的多克隆抗体,并通过免疫组化证实其在结直肠癌组织中高表达,提示MUC3A可能作为肿瘤进展的潜在标志物。

2. **文献名称**:*Role of MUC3A in Intestinal Barrier Function: Insights from Antibody-Based Knockdown Studies*

**作者**:Chen L, et al.

**摘要**:利用抗MUC3A抗体抑制肠道上皮细胞中MUC3A的糖基化修饰,发现其缺失导致紧密连接蛋白破坏,表明MUC3A对维持肠道屏障完整性具有关键作用。

3. **文献名称**:*Differential Expression of MUC3A in Inflammatory Bowel Disease: A Comparative Study with Commercial Antibodies*

**作者**:Garcia R, et al.

**摘要**:通过对比市售MUC3A抗体的特异性,发现克罗恩病患者肠道黏膜中MUC3A表达显著下调,提示其与疾病炎症反应相关。

4. **文献名称**:*MUC3A Antibody Validation for Flow Cytometry in Ovarian Cancer Cell Lines*

**作者**:Kim S, et al.

**摘要**:验证了MUC3A抗体在流式细胞术中的应用,证实其在卵巢癌细胞表面异常表达,可能为靶向治疗提供新方向。

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**备注**:以上为模拟示例,实际文献需通过PubMed、Web of Science等平台检索关键词“MUC3A antibody”、“MUC3A mucin”等获取。建议结合研究领域(如癌症、肠道疾病等)进一步筛选。

       

背景信息

MUC3A (Mucin 3A), a member of the transmembrane mucin family, is a high-molecular-weight glycoprotein primarily expressed in epithelial cells of the gastrointestinal tract, respiratory system, and other mucosal surfaces. It plays a critical role in maintaining mucosal barrier integrity, lubrication, and cellular signaling. Structurally, MUC3A contains a large extracellular domain with tandem repeat regions rich in serine, threonine, and proline residues, which undergo extensive O-glycosylation, contributing to its gel-forming properties and resistance to proteolytic degradation. Dysregulation of MUC3A has been implicated in pathologies such as inflammatory bowel disease (IBD), colorectal cancer, and cystic fibrosis, where its overexpression or altered glycosylation patterns may influence tumor progression, metastasis, or microbial interactions.

Antibodies targeting MUC3A are essential tools for studying its expression, localization, and functional roles. They are widely used in immunohistochemistry (IHC), Western blotting, and flow cytometry to assess tissue-specific distribution or disease-associated changes. However, developing specific anti-MUC3A antibodies remains challenging due to the protein’s structural complexity, variable glycosylation, and homology with other mucin family members (e.g., MUC12. MUC17). Recent studies explore MUC3A’s potential as a diagnostic biomarker or therapeutic target, particularly in cancers where it may modulate cell adhesion, immune evasion, or chemoresistance. Commercial antibodies often target epitopes in the variable tandem repeat or cytoplasmic domains, though validation for assay-specific contexts (e.g., glycan masking) is critical to ensure accuracy. Ongoing research aims to clarify its mechanistic roles in mucosal homeostasis and disease, driving demand for reliable MUC3A-specific reagents.

       
关键字: MUC3A抗体;MUC3A;MUC3A Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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