PAK3抗体,Rabbit Polyclonal PAK3 Antibody
  • PAK3抗体,Rabbit Polyclonal PAK3 Antibody
  • PAK3抗体,Rabbit Polyclonal PAK3 Antibody
  • PAK3抗体,Rabbit Polyclonal PAK3 Antibody

PAK3抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-09
QQ交谈 微信洽谈

产品详情

中文名称:PAK3抗体英文名称:Rabbit Polyclonal PAK3 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 200 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: PAK3
2025-05-09 PAK3抗体 Rabbit Polyclonal PAK3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 200 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesbPAK; MRX30; MRX47; OPHN3; hPAK3; CDKN1A; PAK3beta
WB Predicted band size62 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human PAK3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: P04410(PAK3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P04410(PAK3 Antibody) at dilution 1/25. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P04410(PAK3 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是3-4篇关于PAK3抗体的参考文献示例(注:内容为模拟概括,非真实文献,仅供格式参考):

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1. **文献名称**: "PAK3 regulates synaptic plasticity and neuronal connectivity in the hippocampus"

**作者**: Allen, K.M., et al.

**摘要**: 本研究利用特异性PAK3抗体,通过免疫印迹和免疫组化技术,揭示了PAK3蛋白在小鼠海马神经元突触可塑性中的关键作用。结果显示PAK3缺失导致树突棘形态异常,提示其与神经发育障碍相关。

2. **文献名称**: "Expression profiling of PAK3 in human cancer cell lines using a novel monoclonal antibody"

**作者**: Wang, L., et al.

**摘要**: 作者开发了一种高特异性PAK3单克隆抗体,并通过流式细胞术和免疫荧光验证其在多种癌细胞系中的表达差异。研究发现PAK3高表达与肿瘤迁移能力增强相关,为癌症靶向治疗提供潜在标志物。

3. **文献名称**: "PAK3 mutations and protein stability in X-linked intellectual disability"

**作者**: Smith, J.R., et al.

**摘要**: 通过PAK3抗体进行Western blot分析,发现X连锁智力障碍患者的PAK3基因突变导致蛋白稳定性下降。研究强调抗体在诊断PAK3相关遗传性疾病中的临床应用价值。

4. **文献名称**: "Subcellular localization of PAK3 in Alzheimer’s disease models"

**作者**: Chen, Y., et al.

**摘要**: 使用PAK3抗体进行免疫电镜观察,发现阿尔茨海默病模型中PAK3在神经元线粒体的异常聚集,提示其可能参与氧化应激通路调控。

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如需真实文献,建议通过PubMed或Google Scholar搜索关键词“PAK3 antibody”或“PAK3 immunohistochemistry”获取近期研究。

       

背景信息

The PAK3 antibody is a crucial tool for studying the p21-activated kinase 3 (PAK3), a serine/threonine kinase belonging to the PAK family, which plays pivotal roles in cytoskeletal dynamics, cell signaling, and neuronal development. PAK3 is activated by binding to Rho-family GTPases like Cdc42 and Rac, regulating processes such as cell motility, apoptosis, and synaptic plasticity. It is highly expressed in the brain, where it contributes to dendritic spine formation, neuronal connectivity, and cognitive function. Mutations or dysregulation of PAK3 are linked to neurodevelopmental disorders, including X-linked intellectual disability and autism spectrum disorders, as well as cancer progression.

PAK3 antibodies are designed to detect specific epitopes of the PAK3 protein, enabling researchers to investigate its expression, localization, and post-translational modifications. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Given the structural homology among PAK family members (PAK1-6), high specificity is critical to avoid cross-reactivity. Many PAK3 antibodies target unique regions, such as the kinase domain or regulatory motifs, to distinguish PAK3 from other isoforms.

Research utilizing PAK3 antibodies has advanced understanding of its role in diseases and potential therapeutic targeting. For example, studies reveal PAK3's involvement in β-amyloid toxicity in Alzheimer’s models and its oncogenic signaling in breast and gastric cancers. Validating antibody specificity through knockout controls or siRNA remains essential for reliable data interpretation. Overall, PAK3 antibodies are indispensable for unraveling the kinase's multifaceted functions in health and disease.

       
关键字: PAK3抗体;PAK3;PAK3 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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