SFTPA1抗体

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     Gel: 12%SDS-PAGE, Lysate: 50 μg, Lane 1-2: Human fetal lung tissue, A549 cells, Primary antibody: P04465(SFTPA1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P04465(SFTPA1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The surfactant protein A1 (SFTPA1) antibody is a tool used to detect and study SFTPA1. a critical component of pulmonary surfactant produced primarily by alveolar type II cells. SFTPA1 belongs to the collectin family, playing essential roles in innate lung immunity by opsonizing pathogens, modulating inflammatory responses, and regulating surfactant homeostasis. It binds to microbial surfaces, facilitating their clearance by alveolar macrophages, and interacts with immune cells to balance pro- and anti-inflammatory signals.

SFTPA1 antibodies are widely employed in research to investigate pulmonary diseases such as idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), and acute respiratory distress syndrome (ARDS), where SFTPA1 expression or function may be altered. These antibodies enable techniques like immunohistochemistry, Western blotting, and ELISA to localize, quantify, or analyze SFTPA1's structural modifications in tissues or biological fluids. Commercially available monoclonal or polyclonal SFTPA1 antibodies vary in specificity, with some cross-reacting with its homolog SFTPA2 due to high sequence similarity. Challenges include ensuring target specificity and optimizing protocols for different sample types. Additionally, SFTPA1 autoantibodies have been implicated in certain autoimmune lung disorders, making these reagents valuable for both basic and clinical studies exploring surfactant dysfunction or immune dysregulation.