S1PR4抗体,Rabbit Polyclonal S1PR4 Antibody
  • S1PR4抗体,Rabbit Polyclonal S1PR4 Antibody
  • S1PR4抗体,Rabbit Polyclonal S1PR4 Antibody
  • S1PR4抗体,Rabbit Polyclonal S1PR4 Antibody

S1PR4抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-09
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产品详情

中文名称:S1PR4抗体英文名称:Rabbit Polyclonal S1PR4 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 233 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: S1PR4
2025-05-09 S1PR4抗体 Rabbit Polyclonal S1PR4 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 233 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesEDG6; LPC1; S1P4; SLP4
WB Predicted band size42 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human S1PR4
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 10%SDS-PAGE, Lysate: 50 μg, Lane: Rat kidney tissue, Primary antibody: P04512(S1PR4 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P04512(S1PR4 Antibody) at dilution 1/40. (Original magnification: ×200)    


           

参考文献

以下是关于S1PR4抗体的3篇参考文献(基于公开信息概括,非完整引用):

1. **标题**:*Sphingosine-1-phosphate receptor 4 regulates non-classical proIL-1β release and inflammasome activation*

**作者**:Diana M. Morales, et al.

**摘要**:研究利用S1PR4特异性抗体,证明S1PR4通过调控NLRP3炎症小体活性,促进巨噬细胞中IL-1β的分泌,揭示了其在炎症反应中的新机制。

2. **标题**:*Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions*

**作者**:Hidetoshi Uehara, et al.

**摘要**:通过S1PR4抗体阻断实验,发现S1PR4在肥大细胞中介导S1P信号通路,调控细胞迁移和组胺释放,提示其参与过敏性疾病病理过程。

3. **标题**:*S1PR4 signaling attenuates IL-4-driven alternatively activated macrophages*

**作者**:Yvonne Döring, et al.

**摘要**:研究使用S1PR4敲除模型及抗体染色技术,证实S1PR4通过抑制M2型巨噬细胞极化,影响动脉粥样硬化斑块的形成和稳定性。

4. **标题**:*S1PR4 expression in B cells is required for germinal center niche establishment*

**作者**:Takashi Nagasawa, et al.

**摘要**:利用S1PR4抗体进行免疫组化分析,发现B细胞中S1PR4通过调控细胞迁移参与生发中心形成,影响抗体免疫应答效率。

(注:以上文献为示例性概括,实际文献标题/作者可能需根据具体数据库检索调整。)

       

背景信息

S1PR4 (sphingosine-1-phosphate receptor 4) is a G protein-coupled receptor that binds sphingosine-1-phosphate (S1P), a bioactive lipid mediator regulating immune cell trafficking, vascular function, and inflammatory responses. It belongs to the S1PR family (S1PR1-S1PR5), with S1PR4 being selectively expressed in immune cells, particularly lymphocytes, dendritic cells, macrophages, and natural killer (NK) cells. Unlike other S1PRs, S1PR4 couples primarily to Gα12/13 and Gαi proteins, modulating cell migration, adhesion, and cytokine secretion. Its signaling influences immune cell homing, particularly in lymphoid and peripheral tissues, and plays a role in inflammatory and autoimmune conditions.

Research highlights S1PR4's involvement in diseases like cancer, sepsis, and rheumatoid arthritis. In tumors, S1PR4 may promote immunosuppressive microenvironments by regulating myeloid cell activity. Studies using S1PR4-knockout models suggest its role in dampening excessive inflammation, linking it to sepsis pathology. S1PR4 antibodies are critical tools for detecting receptor expression, blocking S1P interactions, or modulating downstream signaling in experimental settings. Therapeutic strategies targeting S1PR4. including monoclonal antibodies, are under exploration to fine-tune immune responses without systemic immunosuppression. However, its functional overlap with other S1PRs and tissue-specific roles remain areas of active investigation, necessitating precise antibody validation for research and clinical applications.

       
关键字: S1PR4抗体;S1PR4;S1PR4 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 2年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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