KLHL11抗体 新品

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     Western blot analysis using KLHL11 mouse mAb against Hela (1) and MCF-7 (2) cell lysate.    

  
  

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     Immunofluorescence analysis of 3T3-L1 cells using KLHL11 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    

  
  

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     Flow cytometric analysis of K562 cells using KLHL11 mouse mAb (green) and negative control (purple).    

  
  

KLHL11 (Kelch-like protein 11) is a member of the Kelch-like protein family, characterized by its N-terminal BTB/POZ domain and C-terminal Kelch repeat motifs. These structural features enable KLHL11 to act as a substrate recognition component of Cullin-RING E3 ubiquitin ligase (CRL) complexes, facilitating the targeted ubiquitination and subsequent proteasomal degradation of specific proteins. KLHL11 has garnered attention for its role in cellular processes such as protein homeostasis, cytoskeletal organization, and transcriptional regulation. Dysregulation of KLHL11 is implicated in pathological conditions, including cancers and neurological disorders.

KLHL11 antibodies are critical tools for studying its expression, localization, and function. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess KLHL11 protein levels in tissues or cell lines. Notably, KLHL11 has been identified as an autoantigen in paraneoplastic neurological syndromes, particularly in association with small cell lung cancer (SCLC). Antibodies against KLHL11 in patient sera serve as diagnostic biomarkers for these rare autoimmune disorders, linking malignancy to neurological autoimmunity. Research also explores KLHL11's tumor-suppressive roles in certain cancers, where its loss may promote oncogenesis. Commercial KLHL11 antibodies are typically validated for specificity and sensitivity, though variability between clones necessitates careful experimental optimization. Ongoing studies aim to clarify its interactome and therapeutic potential.