CD94抗体 新品

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     Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);    

  
  

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     Flow cytometric analysis of RAJI cells using CD94 mouse mAb (green) and negative control (purple).    

  
  

CD94 antibodies target the CD94 protein, a C-type lectin receptor primarily expressed on natural killer (NK) cells and subsets of T cells. CD94 typically forms heterodimers with members of the NKG2 family (e.g., NKG2A or NKG2C) to create receptors that recognize HLA-E molecules on antigen-presenting cells. This interaction allows NK cells to monitor HLA-E expression, which indirectly reflects the levels of classical MHC class I molecules. CD94/NKG2A functions as an inhibitory receptor, transmitting signals through immunoreceptor tyrosine-based inhibitory motifs (ITIMs), while CD94/NKG2C acts as an activating receptor via association with adaptor proteins like DAP12.

CD94 antibodies are essential tools for studying NK cell biology, immune regulation, and disease mechanisms. They enable detection of CD94 surface expression by flow cytometry, facilitate functional studies (e.g., blocking receptor-ligand interactions), and help distinguish NK cell subsets. In research, these antibodies have clarified roles of CD94/NKG2 receptors in viral infections (e.g., cytomegalovirus), cancer immunosurveillance, and autoimmune disorders. Therapeutic applications are also explored, as modulating CD94/NKG2 pathways could enhance NK cell responses against malignancies or dampen excessive inflammation. Their specificity makes them valuable for dissecting HLA-E-mediated immune tolerance and pathogen evasion strategies.