JUP抗体

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     Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);    

  
  

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     Western blot analysis using JUP mouse mAb against T47D (1), MCF-7 (2), SKBR-3 (3), A431 (4) and HEK293 (5) cell lysate.    

  
  

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     Immunofluorescence analysis of U251 cells using JUP mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human rectum tissues using JUP mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human stomach cancer tissues using JUP mouse mAb with DAB staining.    

  
  

JUP antibody targets junction plakoglobin (JUP), a key component of cell-cell adhesion structures, primarily found in desmosomes and adherens junctions. Encoded by the *JUP* gene, plakoglobin belongs to the armadillo protein family and plays dual roles in maintaining tissue integrity by linking cadherins to the cytoskeleton and modulating intracellular signaling pathways. It is structurally and functionally related to β-catenin, sharing roles in Wnt signaling, though with distinct regulatory mechanisms. JUP’s involvement in intercellular adhesion makes it critical in tissues subjected to mechanical stress, such as the skin and heart.

Dysregulation of JUP is linked to several pathologies. Mutations in *JUP* are associated with arrhythmogenic right ventricular cardiomyopathy (ARVC), a heart condition characterized by fibrofatty tissue replacement, and skin disorders like Naxos disease. In cancer, altered JUP expression has been observed in malignancies such as melanoma and breast cancer, where it may act as a tumor suppressor or promoter depending on context. Reduced JUP levels often correlate with poor prognosis and metastatic behavior.

JUP antibodies are widely used in research and diagnostics to study desmosomal integrity, cardiac and cutaneous diseases, and cancer progression. They enable detection of JUP localization and expression levels via techniques like immunohistochemistry and Western blotting. Commercial JUP antibodies are validated for specificity across human and model organisms, aiding mechanistic studies of cell adhesion, signaling crosstalk, and therapeutic targeting in JUP-related disorders.