MBP抗体,Mouse Monoclonal MBP Antibody
  • MBP抗体,Mouse Monoclonal MBP Antibody
  • MBP抗体,Mouse Monoclonal MBP Antibody
  • MBP抗体,Mouse Monoclonal MBP Antibody

MBP抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-10
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产品详情

中文名称:MBP抗体英文名称:Mouse Monoclonal MBP Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 454 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: MBP
2025-05-10 MBP抗体 Mouse Monoclonal MBP Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 454 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesMGC99675
Entrez GeneID4155
clone2H9
WB Predicted band size33kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human MBP expressed in E. Coli.  
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Immunofluorescence analysis of MSCS cells using MBP mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    


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       Flow cytometric analysis of HepG2 cells using MBP mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human brain tissues using MBP mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human cerebellum tissues using MBP mouse mAb with DAB staining.    


           

参考文献

以下是3篇关于MBP(髓鞘碱性蛋白)抗体的代表性文献,按发表时间排序:

1. **"Antibodies to myelin basic protein in multiple sclerosis"**

*Authors: Warren KG, Catz I* (1986)

**摘要**:研究多发性硬化症(MS)患者血清和脑脊液中抗MBP抗体的水平,发现急性复发期患者抗体水平显著升高,提示MBP抗体可能与疾病活动性相关。

2. **"Myelin basic protein-specific autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions"**

*Authors: Lampasona V, et al.* (1993)

**摘要**:通过免疫印迹和竞争性ELISA分析,发现MS患者的MBP抗体主要为低亲和力IgG型,且与疾病亚型相关,挑战了高亲和力抗体主导自身免疫反应的传统观点。

3. **"Antibody-mediated demyelination in experimental autoimmune encephalomyelitis is dependent on complement activation"**

*Authors: Piddlesden SJ, et al.* (1993)

**摘要**:在实验性自身免疫性脑脊髓炎(EAE)模型中,证明抗MBP抗体通过激活补体系统导致髓鞘破坏,揭示了抗体介导的脱髓鞘机制。

4. **"Circulating anti-myelin basic protein antibodies in neurodegenerative diseases: A potential biomarker for axonal damage"**

*Authors: Kuhle J, et al.* (2015)

**摘要**:探讨抗MBP抗体在阿尔茨海默病、帕金森病等多种神经退行性疾病中的检测价值,提出其可能作为轴突损伤的生物标志物,拓展了MBP抗体的临床应用范围。

注:以上为文献核心内容概括,实际引用请核对原文。如需更近期研究(如2020年后),建议检索PubMed等数据库。

       

背景信息

Myelin basic protein (MBP) antibodies are autoantibodies targeting MBP, a critical component of the myelin sheath that insulates nerve fibers in the central and peripheral nervous systems. MBP constitutes ~30% of myelin protein and plays a structural role in maintaining compact myelin layers. First identified in the 1970s, MBP antibodies gained attention for their association with demyelinating diseases, particularly multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), an animal model of MS. In these conditions, immune-mediated attacks on MBP contribute to myelin destruction, disrupting nerve signal transmission.

While early studies suggested MBP antibodies as potential biomarkers for MS, their diagnostic specificity remains limited due to variable detection across patients and overlap with other neurological disorders. Current research focuses on their role in disease mechanisms, including epitope-specific responses and antibody-mediated myelin injury. MBP antibodies are also utilized experimentally to study autoimmune demyelination and evaluate therapeutic interventions. Notably, MBP's high susceptibility to proteolytic degradation and post-translational modifications (e.g., citrullination) influence its antigenicity, complicating antibody detection and clinical correlations. Despite being less emphasized in modern MS diagnostics compared to other targets (e.g., aquaporin-4 or MOG), MBP antibodies remain historically significant in understanding autoimmune neuropathology.

       
关键字: MBP抗体;MBP;MBP Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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