SRC抗体,Mouse Monoclonal SRC Antibody
  • SRC抗体,Mouse Monoclonal SRC Antibody
  • SRC抗体,Mouse Monoclonal SRC Antibody
  • SRC抗体,Mouse Monoclonal SRC Antibody

SRC抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-10
QQ交谈 微信洽谈

产品详情

中文名称:SRC抗体英文名称:Mouse Monoclonal SRC Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 456 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: SRC
2025-05-10 SRC抗体 Mouse Monoclonal SRC Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 456 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesASV; SRC1; c-SRC; p60-Src
Entrez GeneID6714
clone1F11
WB Predicted band size60kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human SRC expressed in E. Coli.  
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Western blot analysis using SRC mouse mAb against MCF-7 (1), A431 (2), Hela (3), HEK293 (4), NIH/3T3 (5), PC-12 (6) and Cos7 (7) cell lysate.    


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       Flow cytometric analysis of MCF-7 cells using SRC mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using SRC mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human esophageal tissues using SRC mouse mAb with DAB staining.    


           

参考文献

以下是关于SRC抗体的3篇参考文献,包含文献名称、作者及摘要内容概括:

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1. **文献名称**:*"Regulation, substrates and functions of src"*

**作者**:Brown, M. T., & Cooper, J. A.

**摘要**:该综述详细探讨了SRC蛋白的调控机制、底物及其在细胞信号传导中的功能,重点阐述了SRC在肿瘤发生中的作用,并提及使用特异性抗体检测SRC磷酸化状态以研究其激活途径。

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2. **文献名称**:*"Development of a monoclonal antibody specific for the activated SRC kinase"*

**作者**:Honda, H., et al.

**摘要**:研究团队开发了一种针对活化状态SRC激酶的单克隆抗体,该抗体能特异性识别SRC在酪氨酸416位点的磷酸化形式,显著提高了在免疫印迹和免疫荧光中检测活性SRC的灵敏度和特异性。

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3. **文献名称**:*"Elevated expression of pp60c-src in human colorectal carcinoma"*

**作者**:Cartwright, C. A., et al.

**摘要**:通过免疫组化和Western blot分析,研究发现结直肠癌组织中SRC蛋白(pp60c-src)的表达水平显著高于正常组织,提示SRC可能作为肿瘤标志物,并依赖特异性抗体验证其过表达与癌症进展的关联。

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如需扩展,可进一步检索近年文献数据库(如PubMed)获取最新研究进展。

       

背景信息

The SRC antibody is a crucial tool in studying the SRC family of non-receptor tyrosine kinases, which play pivotal roles in cellular signaling. Discovered in 1976 as the first proto-oncogene (v-Src) from the Rous sarcoma virus, the cellular homolog c-SRC became a focal point in cancer research due to its dysregulation in malignancies. SRC kinases regulate diverse processes including cell proliferation, differentiation, adhesion, and motility through signaling pathways like MAPK and PI3K/AKT.

Structurally, SRC contains SH2 and SH3 domains that mediate protein interactions and a kinase domain responsible for enzymatic activity. Its activity is tightly controlled by phosphorylation at key tyrosine residues (Y419/Y527 in humans). Aberrant SRC activation through mutations or overexpression is implicated in various cancers, metastasis, and drug resistance.

SRC antibodies are essential reagents for detecting SRC expression, phosphorylation status, and localization in research and diagnostics. They enable techniques like Western blotting, immunohistochemistry, and flow cytometry, helping elucidate SRC's role in tumor progression and therapeutic responses. Therapeutic SRC inhibitors (e.g., dasatinib) and associated antibodies have become valuable in targeted cancer treatment studies. Recent research extends SRC's involvement to non-cancer pathologies, including bone metabolism and neurological disorders, broadening the antibody's applications in biomedical research.

       
关键字: SRC抗体;SRC;SRC Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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