MAP2K7抗体

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     Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    

  
  

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     Immunofluorescence analysis of Hela cells using MAP2K7 mouse mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    

  
  

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     Flow cytometric analysis of Hela cells using MAP2K7 mouse mAb (green) and negative control (red).    

  
  

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     Immunohistochemical analysis of paraffin-embedded human lung cancer tissues using MAP2K7 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human muscle tissues using MAP2K7 mouse mAb with DAB staining.    

  
  

The MAP2K7 (Mitogen-activated protein kinase kinase 7) antibody is a crucial tool for studying the c-Jun N-terminal kinase (JNK) signaling pathway. MAP2K7. also known as MKK7. is a dual-specificity kinase that phosphorylates and activates JNKs (MAPKs) in response to cytokines, stress, or growth factors. It plays a pivotal role in regulating cellular processes such as apoptosis, inflammation, differentiation, and proliferation. Dysregulation of MAP2K7 has been linked to cancer, neurodegenerative disorders, and autoimmune diseases, making it a target for therapeutic research.

MAP2K7 antibodies are designed to detect either the total protein or specific phosphorylated forms (e.g., at Ser271/Thr275) to assess activation status. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study MAP2K7 expression, localization, and signaling dynamics in cell lines, tissues, or disease models. Both monoclonal and polyclonal variants exist, offering flexibility in experimental design. Validation typically includes knockout/knockdown controls to confirm specificity. Researchers leverage these antibodies to explore MAP2K7's role in stress responses, immune regulation, and its interplay with other pathways (e.g., MAPK/ERK). Understanding MAP2K7 activity aids in deciphering disease mechanisms and identifying potential biomarkers or drug targets.