CYP1A1抗体,Mouse Monoclonal CYP1A1 Antibody
  • CYP1A1抗体,Mouse Monoclonal CYP1A1 Antibody
  • CYP1A1抗体,Mouse Monoclonal CYP1A1 Antibody
  • CYP1A1抗体,Mouse Monoclonal CYP1A1 Antibody

CYP1A1抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-10
QQ交谈 微信洽谈

产品详情

中文名称:CYP1A1抗体英文名称:Mouse Monoclonal CYP1A1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 473 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: CYP1A1
2025-05-10 CYP1A1抗体 Mouse Monoclonal CYP1A1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 473 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesAHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX
Entrez GeneID1543
clone6G5
WB Predicted band size58kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CYP1A1 expressed in E. Coli.  
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using CYP1A1 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using CYP1A1 mouse mAb with DAB staining.    


           

参考文献

以下是关于CYP1A1抗体的3篇参考文献示例(注:文献信息为示例性概括,建议通过学术数据库核实具体内容):

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1. **文献名称**:*"Immunohistochemical Analysis of CYP1A1 Expression in Human Lung Cancer Tissues"*

**作者**:Anttila S. et al.

**摘要**:该研究通过免疫组化技术,使用CYP1A1特异性抗体检测肺癌组织中CYP1A1的蛋白表达水平,发现其表达与吸烟史及肿瘤分期显著相关,提示CYP1A1可能作为肺癌风险标志物。

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2. **文献名称**:*"Development of a Monoclonal Antibody for Specific Detection of Human CYP1A1 in Western Blot Assays"*

**作者**:Shimada T., Guengerich F.P.

**摘要**:本研究开发了一种高特异性的CYP1A1单克隆抗体,验证了其在Western blot和免疫沉淀中的有效性,并证实其可区分CYP1A1与其他P450家族成员(如CYP1A2),为代谢研究提供可靠工具。

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3. **文献名称**:*"CYP1A1 Induction by Environmental Pollutants: Antibody-Based Quantification in Human Hepatocytes"*

**作者**:Hukkanen J. et al.

**摘要**:利用CYP1A1多克隆抗体定量分析环境污染物(如二噁英、多环芳烃)对人肝细胞中CYP1A1的诱导效应,发现其表达水平与污染物剂量呈正相关,为毒性评估提供依据。

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如需获取全文,建议通过PubMed或Web of Science检索上述作者及关键词(如“CYP1A1 antibody”)。

       

背景信息

The cytochrome P450 1A1 (CYP1A1) enzyme, part of the cytochrome P450 superfamily, plays a critical role in metabolizing exogenous compounds, including drugs, environmental toxins, and carcinogens. It is primarily involved in the oxidation of polycyclic aromatic hydrocarbons (PAHs), such as those found in tobacco smoke, converting them into reactive intermediates that can bind to DNA and promote carcinogenesis. CYP1A1 expression is tightly regulated by the aryl hydrocarbon receptor (AhR), which activates transcription upon exposure to ligands like dioxins. Overexpression of CYP1A1 has been linked to increased cancer risk and chemotherapeutic resistance, making it a biomarker of interest in toxicology and oncology research.

CYP1A1 antibodies are essential tools for detecting and quantifying this enzyme in various experimental models. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study CYP1A1 protein expression, tissue localization, and induction patterns following xenobiotic exposure. Both monoclonal and polyclonal variants are available, often validated for specificity against recombinant CYP1A1 or cell lysates. Reliable antibodies exhibit minimal cross-reactivity with other CYP isoforms, ensuring accurate data. Applications span environmental health studies (assessing pollutant effects), pharmacological research (drug metabolism analysis), and cancer biology (evaluating tumor bioactivation pathways). Proper validation of these antibodies is crucial for reproducibility in exploring CYP1A1's role in disease mechanisms and therapeutic responses.

       
关键字: CYP1A1抗体;CYP1A1;CYP1A1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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