GABBR2抗体,Mouse Monoclonal GABBR2 Antibody
  • GABBR2抗体,Mouse Monoclonal GABBR2 Antibody
  • GABBR2抗体,Mouse Monoclonal GABBR2 Antibody
  • GABBR2抗体,Mouse Monoclonal GABBR2 Antibody

GABBR2抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-10
QQ交谈 微信洽谈

产品详情

中文名称:GABBR2抗体英文名称:Mouse Monoclonal GABBR2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 637 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: GABBR2
2025-05-10 GABBR2抗体 Mouse Monoclonal GABBR2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 637 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesHG20; GPR51; GPRC3B; GABABR2; HRIHFB2099
Entrez GeneID9568
clone5G7F7
WB Predicted band size105.8kDa
Host/IsotypeMouse IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human GABBR2 (AA: 319-483) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Immunofluorescence analysis of Hela cells using GABBR2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Secondary antibody from Fisher (Cat#: 35503)    


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       Immunohistochemical analysis of paraffin-embedded human cerebellum tissues using GABBR2 mouse mAb with DAB staining.    


           

参考文献

以下是关于GABBR2抗体的参考文献示例(注:内容为概括性示例,建议通过PubMed或Google Scholar验证真实文献):

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1. **"Development and characterization of a specific antibody for GABBR2 receptor subunit"**

*Authors: Smith A, et al.*

摘要:本研究报道了一种新型兔源多克隆抗体的开发,该抗体特异性靶向GABBR2受体亚基。通过免疫印迹和免疫组化验证,证明其在啮齿类动物及人类脑组织中的高特异性,为研究GABBR2在中枢神经系统的表达分布提供了工具。

2. **"GABBR2 expression in autism spectrum disorder: Insights from post-mortem brain analysis"**

*Authors: Chen L, et al.*

摘要:利用GABBR2特异性抗体对自闭症患者脑组织进行免疫染色,发现皮层和海马区GABBR2蛋白表达显著下调,提示GABBR2异常可能与自闭症的突触功能障碍相关。

3. **"Role of GABBR2 in epilepsy: Antibody-based detection in rodent models"**

*Authors: Tanaka K, et al.*

摘要:通过Western blot和免疫荧光技术,结合抗GABBR2抗体,发现癫痫模型小鼠海马区GABBR2表达动态变化,表明其在抑制性信号通路中起关键作用,可能成为治疗靶点。

4. **"GABBR2 antibody validation for flow cytometry in immune cells"**

*Authors: Müller S, et al.*

摘要:本文验证了商用GABBR2抗体在流式细胞术中的应用,证实其在T细胞和树突状细胞表面的表达,拓展了GABBR2在免疫调控研究中的潜在作用。

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建议通过学术数据库检索真实文献,关键词:**GABBR2 antibody + specific application(e.g., Western blot, neurodevelopmental disorders)**。

       

背景信息

The GABBR2 antibody is a crucial tool for studying the GABA B receptor subunit 2 (GABBR2), a component of the GABA B receptor, a class C G-protein-coupled receptor (GPCR) central to inhibitory neurotransmission. GABA B receptors function as heterodimers, requiring both GABBR1 and GABBR2 subunits for proper trafficking and signaling. GABBR2 plays a key role in coupling receptor activation to downstream effectors, such as G proteins and ion channels, modulating synaptic transmission, neuronal excitability, and long-term plasticity. It is widely expressed in the central and peripheral nervous systems, influencing processes like anxiety, pain perception, and cognitive function.

Antibodies targeting GABBR2 enable researchers to investigate its expression, localization, and interactions in tissues and cell models. They are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study receptor distribution under physiological and pathological conditions. Dysregulation of GABBR2 has been implicated in neurological and psychiatric disorders, including epilepsy, schizophrenia, and addiction, making it a potential therapeutic target.

Commercial GABBR2 antibodies are typically raised in rabbits or mice using synthetic peptides or recombinant protein fragments. Specificity is validated through knockout controls or siRNA knockdowns. Researchers must verify antibody performance in their experimental systems due to potential cross-reactivity with related proteins or tissue-specific isoforms. These tools advance our understanding of GABA B receptor biology and its role in disease mechanisms.

       
关键字: GABBR2抗体;GABBR2;GABBR2 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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