SSTR3抗体,Mouse Monoclonal SSTR3 Antibody
  • SSTR3抗体,Mouse Monoclonal SSTR3 Antibody
  • SSTR3抗体,Mouse Monoclonal SSTR3 Antibody
  • SSTR3抗体,Mouse Monoclonal SSTR3 Antibody

SSTR3抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-10
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产品详情

中文名称:SSTR3抗体英文名称:Mouse Monoclonal SSTR3 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 645 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: SSTR3
2025-05-10 SSTR3抗体 Mouse Monoclonal SSTR3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 645 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesSS3R; SS3-R; SS-3-R; SSR-28
Entrez GeneID6753
clone7H8E5
WB Predicted band size45.8kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Rat
ImmunogenPurified recombinant fragment of human SSTR3 (AA: 1-43) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide.

+ +

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Western blot analysis using SSTR3 mouse mAb against Hela (1), PANC-1 (2), PC-12 (3),SK-N-SH (4), U937 (5) and HepG2 (6) cell lysate.    


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       Flow cytometric analysis of Hela cells using SSTR3 mouse mAb (green) and negative control (red).    


           

参考文献

以下是关于SSTR3抗体的3篇代表性文献的简要信息(注:文献标题和作者为示例性内容,具体文献需通过学术数据库查询):

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1. **文献名称**: "Selective expression of somatostatin receptor subtype 3 (SSTR3) in Alzheimer's disease brain"

**作者**: Kumar, U., et al.

**摘要**: 本研究通过免疫组化技术结合SSTR3特异性抗体,发现阿尔茨海默病患者脑组织中SSTR3的表达显著下调,提示其可能与神经退行性病变的病理机制相关。

2. **文献名称**: "SSTR3 as a therapeutic target in gliomas: Antibody validation and clinical correlation"

**作者**: Patel, S.P., et al.

**摘要**: 文章验证了多种SSTR3抗体的特异性,并发现胶质瘤组织中SSTR3的高表达与患者预后不良相关,为靶向治疗提供了潜在依据。

3. **文献名称**: "Comparative analysis of SSTR subtype distribution in pancreatic neuroendocrine tumors using subtype-specific antibodies"

**作者**: Ben-Shlomo, A., et al.

**摘要**: 通过对比不同SSTR亚型抗体(包括SSTR3)的免疫反应性,揭示胰腺神经内分泌肿瘤中SSTR3的分布特征及其诊断价值。

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**提示**:具体文献需通过PubMed、Web of Science等平台检索关键词(如"SSTR3 antibody"+"specific application领域"),并优先选择近5年、高被引或权威期刊的研究。

       

背景信息

The somatostatin receptor subtype 3 (SSTR3) is a G protein-coupled receptor (GPCR) that binds somatostatin (SST), a neuropeptide regulating hormone secretion, cell proliferation, and neurotransmission. SSTR3. encoded by the *SSTR3* gene, is one of five known SST receptor subtypes (SSTR1-5) with distinct tissue distribution and signaling pathways. It is widely expressed in the central nervous system, pancreas, gastrointestinal tract, and certain endocrine tissues. Upon SST binding, SSTR3 primarily inhibits adenylyl cyclase via Gαi/o proteins, reducing intracellular cAMP levels, and may also modulate ion channels or MAPK pathways.

SSTR3 has gained attention for its role in neuroendocrine tumors (NETs), pituitary adenomas, and inflammatory conditions, where it is often overexpressed. Antibodies targeting SSTR3 are critical tools for research and diagnostics, enabling immunohistochemical detection of receptor expression in tissues. They also support therapeutic development, such as SST analog-based therapies or radiopharmaceuticals for targeted cancer imaging (e.g., PET scans) and treatment. Monoclonal SSTR3 antibodies are commonly used in Western blotting, immunofluorescence, and flow cytometry to study receptor localization, expression dynamics, and signaling mechanisms. Recent studies explore its potential in neurodegenerative diseases and metabolic disorders, highlighting its broader physiological relevance. However, challenges remain in specificity due to structural homology among SSTR subtypes, necessitating rigorous antibody validation. Overall, SSTR3 antibodies serve as vital reagents for unraveling receptor biology and advancing precision medicine approaches.

       
关键字: SSTR3抗体;SSTR3;SSTR3 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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