CCNA2抗体,Mouse Monoclonal CCNA2 Antibody
  • CCNA2抗体,Mouse Monoclonal CCNA2 Antibody
  • CCNA2抗体,Mouse Monoclonal CCNA2 Antibody
  • CCNA2抗体,Mouse Monoclonal CCNA2 Antibody

CCNA2抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-10
QQ交谈 微信洽谈

产品详情

中文名称:CCNA2抗体英文名称:Mouse Monoclonal CCNA2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 702 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: CCNA2
2025-05-10 CCNA2抗体 Mouse Monoclonal CCNA2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 702 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesCCN1; CCNA
Entrez GeneID890
clone6B4D11
WB Predicted band size48.6kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CCNA2 (AA: 105-233) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Western blot analysis using CCNA2 mouse mAb against Hela (1), HEK293 (2), Jurkat (3), K562 (4), SK-Br-3 (5), NIH/3T3 (6) cell lysate.    


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       Flow cytometric analysis of A431 cells using CCNA2 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using CCNA2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using CCNA2 mouse mAb with DAB staining.    


           

参考文献

以下是关于CCNA2抗体的模拟参考文献示例(仅供参考,实际文献请通过学术数据库查询):

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1. **"Cyclin A2 Expression in Colorectal Cancer: Correlation with Clinical Outcomes"**

*Authors: Zhang L, Wang Y, Chen H*

**摘要**:研究通过免疫组化(使用CCNA2特异性抗体)分析结直肠癌组织中Cyclin A2的表达水平,发现其高表达与肿瘤进展和患者生存率降低显著相关。

2. **"Development and Validation of a High-Affinity Anti-CCNA2 Antibody for Cell Cycle Studies"**

*Authors: Tanaka K, Sato R, Yamamoto T*

**摘要**:报道一种新型CCNA2单克隆抗体的开发,验证其在流式细胞术和Western blot中的应用,证实其对细胞周期S/G2/M期检测的特异性。

3. **"CCNA2 as a Potential Therapeutic Target in Hepatocellular Carcinoma"**

*Authors: Gupta S, Patel M, Kumar D*

**摘要**:利用CCNA2抗体研究肝癌细胞中Cyclin A2的功能,发现其沉默可抑制肿瘤增殖,提示其作为治疗靶点的潜力。

4. **"Cyclin A2 Antibody-Based Detection of Replication Stress in Cancer Cells"**

*Authors: Müller J, Fischer A, Braun S*

**摘要**:通过CCNA2抗体结合免疫荧光技术,揭示癌细胞在DNA复制应激下Cyclin A2的异常定位,为抗癌药物筛选提供新方法。

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**提示**:以上为模拟示例,实际文献建议通过PubMed、Google Scholar等平台以关键词“CCNA2 antibody”“Cyclin A2 biomarker”等检索。

       

背景信息

**Background of CCNA2 Antibody**

CCNA2 (Cyclin A2) is a key regulatory protein involved in cell cycle progression, primarily governing the transition from S phase to G2/M phase. It forms complexes with cyclin-dependent kinases (CDKs), such as CDK1 and CDK2. to drive DNA replication and mitotic entry. Dysregulation of CCNA2 expression is implicated in various cancers, where its overexpression often correlates with uncontrolled proliferation, genomic instability, and poor clinical outcomes.

The CCNA2 antibody is a vital tool for detecting and quantifying Cyclin A2 in research. It enables the study of cell cycle dynamics, cancer mechanisms, and therapeutic targets. In laboratory settings, this antibody is used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to analyze CCNA2 expression patterns in tissues or cultured cells. Additionally, it aids in exploring how CCNA2 interacts with CDKs or checkpoint proteins under stress or drug treatment.

Studies utilizing CCNA2 antibodies have revealed its dual role: while essential for normal cell division, its aberrant expression can trigger tumorigenesis. For example, elevated CCNA2 levels are observed in hepatocellular carcinoma, breast cancer, and gliomas, making it a potential biomarker or therapeutic target. Furthermore, research on CCNA2 inhibitors highlights its relevance in precision oncology. Overall, the CCNA2 antibody serves as a critical reagent for advancing our understanding of cell cycle biology and its implications in disease.

       
关键字: CCNA2抗体;CCNA2;CCNA2 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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