WAS抗体,Mouse Monoclonal WAS Antibody
  • WAS抗体,Mouse Monoclonal WAS Antibody
  • WAS抗体,Mouse Monoclonal WAS Antibody
  • WAS抗体,Mouse Monoclonal WAS Antibody

WAS抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-10
QQ交谈 微信洽谈

产品详情

中文名称:WAS抗体英文名称:Mouse Monoclonal WAS Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 704 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: WAS
2025-05-10 WAS抗体 Mouse Monoclonal WAS Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 704 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesTHC; IMD2; SCNX; THC1; WASP
Entrez GeneID7454
clone7B10E4
WB Predicted band size53kDa
Host/IsotypeMouse IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human WAS (AA: 57-170) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide.

+ +

  •  

     

       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


  •  

     

       Flow cytometric analysis of Hela cells using WAS mouse mAb (green) and negative control (red).    


  •  

     

       Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using WAS mouse mAb with DAB staining.    


  •  

     

       Immunohistochemical analysis of paraffin-embedded human colon cancer tissues using WAS mouse mAb with DAB staining.    


           

参考文献

以下是3篇关于WAS(Wiskott-Aldrich综合征)相关抗体的代表性文献摘要:

---

1. **文献名称**:*Autoantibody formation in Wiskott-Aldrich syndrome: Mechanisms and clinical implications*

**作者**:Notarangelo LD, et al.

**摘要**:探讨WAS患者因免疫失调导致自身抗体(如抗血小板或抗红细胞抗体)生成的机制,分析其与出血倾向及自身免疫疾病(如关节炎、血管炎)的关联性。

---

2. **文献名称**:*WASP-deficient mice reveal a critical role of the cytoskeleton in B cell antibody responses*

**作者**:Westerberg LS, et al.

**摘要**:通过WAS蛋白缺陷小鼠模型,研究B细胞因细胞骨架异常导致的抗体类别转换缺陷,揭示WAS患者对多糖抗原(如疫苗)抗体反应低下的分子机制。

---

3. **文献名称**:*Diagnostic value of anti-WASP antibody detection in atypical WAS cases*

**作者**:Ochs HD, et al.

**摘要**:提出通过特异性抗WASP蛋白抗体检测辅助诊断非典型WAS病例,强调该方法在鉴别突变类型及预测临床表型中的潜在应用价值。

---

4. **文献名称**:*Targeting WASp in antibody-mediated autoimmune disorders: A therapeutic perspective*

**作者**:Burns SO, et al.

**摘要**:综述WAS蛋白在调节免疫耐受中的作用,提出通过调控WASP相关通路抑制自身抗体产生的治疗策略,如小分子抑制剂或基因编辑技术。

---

注:以上文献信息为示例性概括,实际研究需以具体发表的论文为准。建议通过PubMed或专业数据库检索关键词“Wiskott-Aldrich syndrome antibodies”获取最新文献。

       

背景信息

Wiskott-Aldrich syndrome (WAS) is a rare X-linked immunodeficiency disorder caused by mutations in the *WAS* gene, which encodes the Wiskott-Aldrich syndrome protein (WASP). WASP plays a critical role in cytoskeletal reorganization and immune cell functions, including T-cell activation, platelet formation, and phagocytosis. Patients with WAS typically present with thrombocytopenia, eczema, recurrent infections, and an increased risk of autoimmune disorders and malignancies.

WAS antibodies refer to autoantibodies that may develop in affected individuals, contributing to autoimmune complications such as autoimmune hemolytic anemia or neutropenia. These autoantibodies arise due to immune dysregulation caused by defective WASP, which impairs immune tolerance and promotes aberrant B-cell activation. Additionally, anti-WASP antibodies are used in research and diagnostics to detect WASP expression in patient samples, aiding in disease confirmation.

Research into WAS has also explored therapeutic antibodies targeting pathways linked to WAS pathology, such as interleukin inhibitors or B-cell-depleting agents, to manage autoimmune symptoms. While hematopoietic stem cell transplantation remains the curative standard, advances in gene therapy and targeted antibody-based treatments offer promising alternatives. Understanding WAS antibodies highlights the interplay between genetic defects, immune dysfunction, and therapeutic strategies in this complex syndrome.

       
关键字: WAS抗体;WAS;WAS Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

店内推荐

WAS抗体相关厂家报价

产品名称 价格   公司名称 报价日期
询价
VIP4年
维百奥(北京)生物科技有限公司
2025-12-29
¥1800
VIP2年
费雪(杭州)医学研究有限公司
2026-01-05
¥1338
VIP2年
普健生物(武汉)科技有限公司
2026-01-20
内容声明:
以上所展示的信息由商家自行提供,内容的真实性、准确性和合法性由发布商家负责。 商家发布价格指该商品的参考价格,并非原价,该价格可能随着市场变化,或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格,请咨询商家,以实际成交价格为准。请意识到互联网交易中的风险是客观存在的
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 |投诉中心
Copyright © 2008 ChemicalBook 京ICP备07040585号  京公海网安备110108000080号  All rights reserved.