LDLR抗体,Mouse Monoclonal LDLR Antibody
  • LDLR抗体,Mouse Monoclonal LDLR Antibody
  • LDLR抗体,Mouse Monoclonal LDLR Antibody
  • LDLR抗体,Mouse Monoclonal LDLR Antibody

LDLR抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-10
QQ交谈 微信洽谈

产品详情

中文名称:LDLR抗体英文名称:Mouse Monoclonal LDLR Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 732 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: LDLR
2025-05-10 LDLR抗体 Mouse Monoclonal LDLR Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 732 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesFH; FHC; LDLCQ2
Entrez GeneID3949
clone1B10H10
WB Predicted band size95.4kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human LDLR (AA: 22-150) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Flow cytometric analysis of Hela cells using LDLR mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human ovarian cancertissues using LDLR mouse mAb with DAB staining.    


           

参考文献

以下是关于LDLR抗体的3篇代表性文献及其摘要:

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1. **标题**: "Monoclonal Antibodies to the Low Density Lipoprotein Receptor as Probes for Study of Receptor-mediated Endocytosis"

**作者**: Beisiegel, U., Schneider, W.J., Goldstein, J.L., Brown, M.S.

**摘要**: 该研究通过制备针对LDLR的单克隆抗体,揭示了抗体与受体结合后阻断LDL内吞的作用机制,证实了LDLR在胆固醇摄取中的关键功能,并为受体介导的内吞途径提供了分子证据。

2. **标题**: "Structural Localization of Epitopes on the LDL Receptor Identified by Monoclonal Antibodies"

**作者**: Russell, D.W., Yamamoto, T., Schneider, W.J. et al.

**摘要**: 作者利用单克隆抗体定位LDLR的表位结构域,发现不同抗体分别结合受体的配体结合区、EGF前体同源区等区域,为解析LDLR的构效关系及遗传突变导致的疾病(如家族性高胆固醇血症)提供了结构基础。

3. **标题**: "Antibody-Mediated Disruption of the Interaction Between PCSK9 and LDLR Enhances LDL Uptake"

**作者**: Zhang, L., McCabe, T., Condra, J.H. et al.

**摘要**: 研究开发了一种靶向PCSK9的单克隆抗体,通过阻断PCSK9与LDLR的结合,减少LDLR的溶酶体降解,从而增加细胞表面LDLR密度,促进血浆LDL-C清除,为治疗高胆固醇血症提供了新策略。

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这些文献涵盖了LDLR抗体的功能研究、结构解析及治疗应用,反映了该领域的关键研究方向。如需具体细节,建议通过学术数据库检索原文。

       

背景信息

Low-density lipoprotein receptor (LDLR) antibodies are tools used to study the LDLR, a cell-surface protein critical for regulating cholesterol homeostasis. LDLR mediates the uptake of LDL cholesterol particles via receptor-mediated endocytosis, a process essential for maintaining plasma cholesterol levels. Dysfunctional LDLR, often due to genetic mutations, is linked to familial hypercholesterolemia (FH), a condition characterized by elevated LDL cholesterol and increased cardiovascular risk.

LDLR antibodies, including monoclonal and polyclonal types, are widely employed in research to detect LDLR expression, track its intracellular trafficking, or modulate its activity. For example, some antibodies act as antagonists to block LDL binding, mimicking therapeutic strategies like PCSK9 inhibitors, which enhance LDLR recycling and lower cholesterol. Conversely, agonist antibodies may stabilize LDLR to boost LDL clearance. These applications make LDLR antibodies valuable in studying atherosclerosis, metabolic disorders, and lipid metabolism pathways.

Additionally, LDLR antibodies have diagnostic potential, aiding in identifying FH patients with receptor defects. Emerging therapeutic approaches also explore antibody-based targeting of LDLR to treat hypercholesterolemia or cancers where LDLR is overexpressed. However, challenges remain in ensuring specificity and minimizing off-target effects. Overall, LDLR antibodies serve as pivotal reagents in both basic research and translational studies of cholesterol-related diseases.

       
关键字: LDLR抗体;LDLR;LDLR Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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