SK2抗体,Mouse Monoclonal SK2 Antibody
  • SK2抗体,Mouse Monoclonal SK2 Antibody
  • SK2抗体,Mouse Monoclonal SK2 Antibody
  • SK2抗体,Mouse Monoclonal SK2 Antibody

SK2抗体 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-10
QQ交谈 微信洽谈

产品详情

中文名称:SK2抗体英文名称:Mouse Monoclonal SK2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 798 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: SK2
2025-05-10 SK2抗体 Mouse Monoclonal SK2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 798 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesSPHK2; SK-2; SPK 2; SPK-2
Entrez GeneID56848
clone3C8D3
WB Predicted band size69.2kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthesized peptide of human SK2 (AA: 36-52).
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Immunofluorescence analysis of HeLa cells using SK2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of HeLa cells using SK2 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using SK2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissues using SK2 mouse mAb with DAB staining.    


           

参考文献

以下是关于SK2抗体的3篇参考文献及其摘要概括:

1. **文献名称**: "Small-conductance calcium-activated potassium channels: insights into their roles in cardiovascular disease"

**作者**: Bond, C.T., et al.

**摘要**: 该研究利用特异性SK2抗体,在小鼠心脏和脑组织中定位SK2通道蛋白,发现其在调节神经元兴奋性和心脏节律中起关键作用,抗体应用证实了SK2在心肌细胞中的高表达。

2. **文献名称**: "SK2 channel regulation of neuronal excitability and behavior in learning and memory"

**作者**: Allen, D., et al.

**摘要**: 通过SK2抗体进行免疫组化和Western blot分析,研究发现海马区SK2通道通过调控突触后电流影响突触可塑性,抗体实验显示SK2缺失导致小鼠空间记忆能力下降。

3. **文献名称**: "Pharmacological modulation of SK2 channels alters dendritic excitability and synaptic plasticity"

**作者**: Lin, M.T., et al.

**摘要**: 该文献使用SK2抗体阻断实验,证明SK2通道在树突信号整合中的作用,抗体介导的功能抑制揭示了其对长时程增强(LTP)的调节机制。

以上研究均通过SK2抗体实现了蛋白定位、功能验证或病理机制探索。

       

背景信息

**Background of SK2 Antibody**

The SK2 antibody targets the small conductance calcium-activated potassium channel protein 2 (SK2. KCa2.2), encoded by the *KCNN2* gene. SK2 channels are voltage-independent potassium channels activated by intracellular calcium, playing critical roles in regulating neuronal excitability, synaptic plasticity, and cardiac rhythmicity. They are predominantly expressed in the brain, particularly in regions like the hippocampus, cortex, and cerebellum, where they modulate afterhyperpolarization currents (IAHP) to influence firing patterns and synaptic transmission. Dysregulation of SK2 channels is implicated in neurological disorders, including epilepsy, ataxia, and cognitive deficits, as well as cardiac arrhythmias.

SK2 antibodies are widely used in neuroscience and cardiovascular research to study channel expression, localization, and function. They enable detection via techniques like Western blot, immunohistochemistry, and immunofluorescence. Studies utilizing SK2 antibodies have revealed its interaction with calmodulin for calcium sensing and its role in diseases, such as spinocerebellar ataxia and atrial fibrillation. Additionally, SK2 channels are explored as therapeutic targets, with modulators under investigation for treating cognitive impairment or arrhythmias. The development of specific SK2 antibodies has been pivotal in advancing understanding of its physiological and pathological mechanisms.

       
关键字: SK2抗体;SK2;SK2 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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