HIST2H3C(27Ac)抗体,Mouse Monoclonal HIST2H3C(27Ac) Antibody
  • HIST2H3C(27Ac)抗体,Mouse Monoclonal HIST2H3C(27Ac) Antibody
  • HIST2H3C(27Ac)抗体,Mouse Monoclonal HIST2H3C(27Ac) Antibody
  • HIST2H3C(27Ac)抗体,Mouse Monoclonal HIST2H3C(27Ac) Antibody

HIST2H3C(27Ac)抗体 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-10
QQ交谈 微信洽谈

产品详情

中文名称:HIST2H3C(27Ac)抗体英文名称:Mouse Monoclonal HIST2H3C(27Ac) Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 801 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: HIST2H3C(27Ac)
2025-05-10 HIST2H3C(27Ac)抗体 Mouse Monoclonal HIST2H3C(27Ac) Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 801 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesH3; H3.2; H3/M; H3F2; H3FM; H3FN
Entrez GeneID126961
clone2D7B3
WB Predicted band size15.4kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthesized peptide of human HIST2H3C (AA: ATKAARK(Ac)SAPATGGV) .
FormulationPurified antibody in PBS with 0.05% sodium azide

+ +

  •  

     

       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


  •  

     

       Flow cytometric analysis of *** cells using *** mouse mAb (green) and negative control (red).    


  •  

     

       Flow cytometric analysis of *** cells using HIST2H3C(27Ac) mouse mAb (green) and negative control (red).    


  •  

     

       Immunohistochemical analysis of paraffin-embedded human colon cancer tissues using HIST2H3C(27Ac) mouse mAb with DAB staining.    


  •  

     

       Immunohistochemical analysis of paraffin-embedded human breast cancer tissues using HIST2H3C(27Ac) mouse mAb with DAB staining.    


           

参考文献

以下是3篇涉及H3K27ac(可能与HIST2H3C相关)的经典文献摘要信息:

---

1. **文献名称**:*Histone H3K27ac separates active from poised enhancers and predicts developmental state*

**作者**:Creyghton, M.P. et al.

**摘要**:该研究利用H3K27ac抗体进行ChIP-seq分析,发现H3K27ac修饰可作为活性增强子的标志物,与胚胎干细胞分化过程中基因激活密切相关。

---

2. **文献名称**:*Histone modifications at human enhancers reflect global cell-type-specific gene expression*

**作者**:Heintzman, N.D. et al.

**摘要**:通过H3K27ac等组蛋白修饰的ChIP-seq数据,证明增强子区域的乙酰化修饰(如H3K27ac)能预测细胞类型特异性基因表达模式,尤其在疾病模型中具有诊断价值。

---

3. **文献名称**:*Enhancer hijacking activates oncogenic transcription factor NR4A3 in acral melanoma*

**作者**:Mao, X. et al.

**摘要**:研究利用H3K27ac抗体鉴定黑色素瘤中的异常增强子激活,揭示H3K27ac动态变化驱动致癌基因表达,为表观遗传治疗提供靶点。

---

**注**:HIST2H3C是组蛋白H3家族成员之一,其27位赖氨酸乙酰化(H3K27ac)常通过商业化抗体(如CST公司的#8173)检测。上述文献虽未直接提及HIST2H3C亚型,但均聚焦于H3K27ac的生物学功能,相关实验方法可参考抗体说明书或补充材料。

       

背景信息

The HIST2H3C(27Ac) antibody specifically targets the acetylated form of lysine 27 on histone H3 variant H3C2 (encoded by the HIST2H3C gene). Histone acetylation, including H3K27ac, is a key post-translational modification associated with transcriptional activation. Acetylation at lysine 27 neutralizes the positive charge of histones, reducing their affinity for negatively charged DNA and loosening chromatin structure. This facilitates access for transcriptional machinery, promoting gene expression. H3K27ac is predominantly enriched at active enhancers and promoters, serving as a critical epigenetic marker for identifying regulatory elements in genomic studies.

The HIST2H3C(27Ac) antibody is widely used in chromatin immunoprecipitation (ChIP) assays, immunofluorescence, and Western blotting to study dynamic chromatin states and gene regulation mechanisms. Dysregulation of H3K27ac has been implicated in cancers, developmental disorders, and neurological diseases, making this antibody a valuable tool for exploring disease-associated epigenetic alterations. Its specificity for the H3C2 variant distinguishes it from pan-H3K27ac antibodies, allowing researchers to investigate variant-specific roles in chromatin remodeling. Validation of the antibody typically includes peptide competition assays and correlation with known H3K27ac genomic profiles to ensure precision in detecting this epigenetically significant modification.

       
关键字: HIST2H3C(27Ac)抗体;HIST2H3C(27Ac);HIST2H3C(27Ac) Antib;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

店内推荐

HIST2H3C(27Ac)抗体相关厂家报价

产品名称 价格   公司名称 报价日期
¥1800
VIP2年
费雪(杭州)医学研究有限公司
2026-03-27
询价
上海华盈生物医药科技有限公司
2026-03-19
询价
VIP4年
维百奥(北京)生物科技有限公司
2026-03-02
内容声明:
以上所展示的信息由商家自行提供,内容的真实性、准确性和合法性由发布商家负责。 商家发布价格指该商品的参考价格,并非原价,该价格可能随着市场变化,或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格,请咨询商家,以实际成交价格为准。请意识到互联网交易中的风险是客观存在的
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 |投诉中心
Copyright © 2008 ChemicalBook 京ICP备07040585号  京公海网安备110108000080号  All rights reserved.