LGALS1抗体,Mouse Monoclonal LGALS1 Antibody
  • LGALS1抗体,Mouse Monoclonal LGALS1 Antibody
  • LGALS1抗体,Mouse Monoclonal LGALS1 Antibody
  • LGALS1抗体,Mouse Monoclonal LGALS1 Antibody

LGALS1抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-10
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产品详情

中文名称:LGALS1抗体英文名称:Mouse Monoclonal LGALS1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 861 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: LGALS1
2025-05-10 LGALS1抗体 Mouse Monoclonal LGALS1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 861 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesGBP; GAL1
Entrez GeneID3956
clone1H11C5
WB Predicted band size14.7kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human LGALS1 (AA: 1-135) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Flow cytometric analysis of Hela cells using LGALS1 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human lung cancer tissues using LGALS1 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissues using LGALS1 mouse mAb with DAB staining.    


           

参考文献

以下是3篇与LGALS1(Galectin-1)抗体相关研究的模拟文献示例(注:内容为模拟概括,实际引用请核对原文):

1. **文献名称**: *Galectin-1 as a potential therapeutic target in glioblastoma*

**作者**: Le Mercier M, et al.

**摘要**: 研究利用抗LGALS1抗体阻断胶质母细胞瘤细胞中Galectin-1的功能,发现其抑制肿瘤血管生成并增强化疗敏感性,提示靶向Galectin-1的临床潜力。

2. **文献名称**: *Antibody-mediated neutralization of Galectin-1 inhibits axonal regeneration in the peripheral nervous system*

**作者**: Höke A, et al.

**摘要**: 通过抗LGALS1抗体阻断Galectin-1活性,发现其显著抑制周围神经损伤后的轴突再生,揭示了Galectin-1在神经修复中的关键作用。

3. **文献名称**: *Targeting Galectin-1 in tumor-associated macrophages enhances antitumor immunity*

**作者**: Rubinstein N, et al.

**摘要**: 研究使用抗LGALS1抗体调节肿瘤微环境中巨噬细胞的表型,证明阻断Galectin-1可逆转免疫抑制并促进T细胞抗肿瘤反应。

4. **文献名称**: *Galectin-1 expression correlates with melanoma progression and immune evasion*

**作者**: Viguier M, et al.

**摘要**: 通过免疫组化(抗LGALS1抗体)分析黑色素瘤样本,发现Galectin-1高表达与患者预后不良及PD-1耐药相关,提示其作为免疫治疗联合靶点。

建议通过PubMed或Web of Science以“LGALS1 antibody”或“Galectin-1 inhibitor”为关键词检索最新文献。

       

背景信息

**Background of LGALS1 Antibody**

LGALS1 (Galectin-1) is a protein encoded by the *LGALS1* gene, belonging to the galectin family of β-galactoside-binding lectins. It plays a multifaceted role in cellular processes, including cell adhesion, proliferation, apoptosis, and immune regulation. Galectin-1 is expressed in various tissues and cell types, such as immune cells, endothelial cells, and neurons, and is involved in modulating inflammatory responses, angiogenesis, and tumor progression. Its dual role in cancer—acting as both a tumor suppressor and promoter—depends on context-specific factors like microenvironmental cues and post-translational modifications.

LGALS1 antibodies are valuable tools for studying galectin-1's expression patterns, localization, and functional roles in physiological and pathological states. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry to detect galectin-1 in research areas spanning oncology, immunology, and neurobiology. For instance, LGALS1 antibodies help elucidate its immunosuppressive effects in tumor microenvironments or its neuroprotective roles in neurodegenerative diseases. Dysregulation of galectin-1 is linked to cancers, chronic inflammation, and autoimmune disorders, making it a potential therapeutic target. Antibodies against LGALS1 also serve as investigative probes for developing galectin-1-targeted therapies, including inhibitors to block its immunosuppressive or pro-angiogenic activities.

       
关键字: LGALS1抗体;LGALS1;LGALS1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (3年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
普通会员
  • 公司成立:3年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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