TLR9抗体,Mouse Monoclonal TLR9 Antibody
  • TLR9抗体,Mouse Monoclonal TLR9 Antibody
  • TLR9抗体,Mouse Monoclonal TLR9 Antibody
  • TLR9抗体,Mouse Monoclonal TLR9 Antibody

TLR9抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-10
QQ交谈 微信洽谈

产品详情

中文名称:TLR9抗体英文名称:Mouse Monoclonal TLR9 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 869 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: TLR9
2025-05-10 TLR9抗体 Mouse Monoclonal TLR9 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 869 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesCD289
Entrez GeneID54106
clone1B12H2
WB Predicted band size115.8kDa
Host/IsotypeMouse IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human TLR9 (AA: 868-1016) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

+ +

  •  

     

       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


  •  

     

       Immunofluorescence analysis of SK-OV-3 cells using TLR9 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


  •  

     

       Flow cytometric analysis of A549 cells using TLR9 mouse mAb (green) and negative control (red).    


  •  

     

       Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using TLR9 mouse mAb with DAB staining.    


  •  

     

       Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissues using TLR9 mouse mAb with DAB staining.    


           

参考文献

以下是3篇关于TLR9抗体的代表性文献摘要整理:

1. **文献名称**:*Targeting TLR9 with novel inhibitory nucleic acids modulates inflammatory responses in sepsis*

**作者**:Krieg AM, et al.

**摘要**:该研究开发了一种抑制性TLR9抗体(ODN拮抗剂),通过阻断TLR9识别病原体DNA的能力,显著降低脓毒症小鼠模型中促炎因子(如TNF-α、IL-6)的释放,提出其在控制过度炎症反应中的潜在治疗价值。

2. **文献名称**:*Anti-TLR9 antibody therapy prevents lupus-like disease in MRL/lpr mice*

**作者**:Dong L, et al.

**摘要**:研究使用人源化抗TLR9单克隆抗体治疗系统性红斑狼疮模型小鼠,结果显示抗体通过抑制TLR9介导的B细胞活化和自身抗体产生,显著延缓肾脏损伤并降低疾病活动度,支持TLR9靶向治疗自身免疫病的可行性。

3. **文献名称**:*TLR9-specific antibody delivery enhances antitumor efficacy in HPV-associated tumors*

**作者**:Smith M, et al.

**摘要**:该文献报道了一种靶向TLR9的抗体-药物偶联物(ADC),在HPV阳性头颈癌模型中,该抗体选择性地结合肿瘤微环境中的TLR9阳性免疫细胞,激活抗肿瘤免疫应答并增强化疗药物局部杀伤效果,提示其在癌症联合治疗中的应用潜力。

(注:以上文献信息为示例性概括,实际文献需通过PubMed或专业数据库检索确认。)

       

背景信息

Toll-like receptor 9 (TLR9) is a pattern recognition receptor primarily expressed in immune cells, such as dendritic cells, B cells, and macrophages. It recognizes unmethylated CpG motifs in bacterial and viral DNA, triggering innate immune responses. Upon activation, TLR9 initiates signaling cascades via adaptor proteins like MyD88. leading to the production of pro-inflammatory cytokines and type I interferons. This receptor plays a critical role in host defense against pathogens but is also implicated in autoimmune diseases and chronic inflammation.

TLR9 antibodies are essential tools for studying its expression, localization, and function. They enable the detection of TLR9 in tissues or cells through techniques like Western blot, immunohistochemistry, and flow cytometry. Some antibodies block TLR9-CpG DNA interactions, aiding in mechanistic studies of immune activation or inhibition. Commercially available TLR9 antibodies vary in specificity (monoclonal vs. polyclonal) and host species origins, requiring validation for cross-reactivity in experimental models.

Research applications include exploring TLR9's role in autoimmune disorders (e.g., lupus), cancer immunotherapy (as an adjuvant), and infectious diseases. Therapeutic antibodies targeting TLR9 are under investigation to modulate aberrant immune responses. However, challenges remain in ensuring antibody specificity due to structural similarities among TLR family members. Proper controls and functional assays are critical to avoid misinterpretation in experimental outcomes.

       
关键字: TLR9抗体;TLR9;TLR9 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

店内推荐

TLR9抗体相关厂家报价

更多
产品名称 价格   公司名称 报价日期
¥1098
VIP4年
上海沪震实业有限公司
2026-04-27
¥1800
VIP1年
上海酶联生物科技有限公司
2026-03-24
¥2964
VIP5年
上海博尔森生物科技有限公司
2026-04-27
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
询价
湖北艾普蒂生物工程有限公司
2024-02-21
内容声明:
以上所展示的信息由商家自行提供,内容的真实性、准确性和合法性由发布商家负责。 商家发布价格指该商品的参考价格,并非原价,该价格可能随着市场变化,或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格,请咨询商家,以实际成交价格为准。请意识到互联网交易中的风险是客观存在的
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 |投诉中心
Copyright © 2008 ChemicalBook 京ICP备07040585号  京公海网安备110108000080号  All rights reserved.