IghA1抗体,Mouse Monoclonal IghA1 Antibody
  • IghA1抗体,Mouse Monoclonal IghA1 Antibody
  • IghA1抗体,Mouse Monoclonal IghA1 Antibody
  • IghA1抗体,Mouse Monoclonal IghA1 Antibody

IghA1抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-10
QQ交谈 微信洽谈

产品详情

中文名称:IghA1抗体英文名称:Mouse Monoclonal IghA1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 885 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: IghA1
2025-05-10 IghA1抗体 Mouse Monoclonal IghA1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 885 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Monkey
IF咨询技术 Human,Mouse,Monkey
IHC1/200 - 1/1000 Human,Mouse,Monkey
ICC1/50 - 1/250 Human,Mouse,Monkey
FCM1/200 - 1/400 Human,Mouse,Monkey
Elisa1/10000 Human,Mouse,Monkey
   

产品详情

AliasesIgA1
Entrez GeneID3493
clone7D5F12
WB Predicted band size37.6kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Monkey
ImmunogenPurified recombinant fragment of human IghA1 (AA: 207-353) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using IghA1 mouse mAb against L1210 (1), THP-1 (2), HepG2 (3), and COS7 (4) cell lysate.    


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       Immunofluorescence analysis of Hela cells using IghA1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of Hela cells using IghA1 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human breast cancer tissues using IghA1 mouse mAb with DAB staining.    


           

参考文献

以下是关于IgA1抗体的3篇参考文献示例(注:IgA1为常见拼写,IghA1可能为笔误或特定变体):

1. **文献名称**: "Autoantibodies against IgA1 glycans in the serum of patients with IgA nephropathy"

**作者**: Tomana, M., et al.

**摘要**: 研究分析了IgA肾病患者的血清,发现其含有针对IgA1铰链区O-糖基化异常的自体抗体,这些抗体可能参与肾小球免疫复合物沉积,导致疾病进展。

2. **文献名称**: "The role of aberrant IgA1 glycosylation in the pathogenesis of IgA nephropathy"

**作者**: Novak, J., et al.

**摘要**: 探讨了IgA1分子糖基化缺陷如何被自身抗体识别,形成循环免疫复合物,并沉积于肾脏,阐明了IgA肾病中自身免疫反应的分子机制。

3. **文献名称**: "IgA1 protease production by Streptococcus pneumoniae promotes immune evasion by cleaving human IgA1"

**作者**: Kerr, M.A., et al.

**摘要**: 揭示了肺炎链球菌通过分泌IgA1蛋白酶切割宿主IgA1抗体,破坏其免疫功能,从而逃避免疫系统攻击的机制,为抗感染治疗提供新靶点。

注:若需特定领域(如肿瘤、自身免疫病)文献,可进一步补充关键词调整检索。

       

背景信息

The IghA1 antibody is a reagent targeting immunoglobulin A1 (IgA1), a subclass of IgA antibodies critical in mucosal immunity. IgA1. predominantly found in serum and mucosal secretions (e.g., saliva, respiratory/gastrointestinal tracts), plays a role in neutralizing pathogens and maintaining immune homeostasis. Structurally, IgA1 differs from IgA2 by an extended hinge region rich in proline and O-glycosylation sites, making it susceptible to cleavage by bacterial proteases—a mechanism pathogens exploit to evade immune detection.

IghA1 antibodies are tools for studying IgA1-specific functions and pathologies. They detect IgA1 in assays, aiding research on IgA nephropathy (IgAN), a kidney disorder linked to galactose-deficient IgA1 immune complexes. These antibodies also help characterize IgA1-producing plasma cell malignancies (e.g., multiple myeloma) and immune deficiencies. Monoclonal IghA1 antibodies are generated via hybridoma or recombinant technologies, often targeting the IgA1 heavy chain or unique epitopes in the hinge region.

Their applications extend to diagnostics, such as quantifying IgA1 in autoimmune or infectious diseases, and therapeutics, including blocking pathogenic IgA1 in IgAN. However, challenges include cross-reactivity with IgA2 or other immunoglobulins, requiring rigorous validation. Overall, IghA1 antibodies remain vital for dissecting IgA1 biology and developing targeted clinical interventions.

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关键字: IghA1抗体;IghA1;IghA1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 2年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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