HLA-DRA抗体,Mouse Monoclonal HLA-DRA Antibody
  • HLA-DRA抗体,Mouse Monoclonal HLA-DRA Antibody
  • HLA-DRA抗体,Mouse Monoclonal HLA-DRA Antibody
  • HLA-DRA抗体,Mouse Monoclonal HLA-DRA Antibody

HLA-DRA抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-10
QQ交谈 微信洽谈

产品详情

中文名称:HLA-DRA抗体英文名称:Mouse Monoclonal HLA-DRA Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 909 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: HLA-DRA
2025-05-10 HLA-DRA抗体 Mouse Monoclonal HLA-DRA Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 909 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC1/100 - 1/500 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesMLRW; HLA-DRA1
Entrez GeneID3122
clone1C11A5
WB Predicted band size28.6kDa
Host/IsotypeMouse IgG2b
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human HLA-DRA (AA: 26-254) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using HLA-DRA mouse mAb against Ramos (1), and Raji (2) cell lysate.    


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       Immunofluorescence analysis of Hela cells using HLA-DRA mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of MCF-7 cells using HLA-DRA mouse mAb (green) and negative control (red).    


           

参考文献

以下是关于HLA-DRA抗体的3篇参考文献示例(内容基于公开研究归纳,非真实文献引用):

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1. **文献名称**:*Autoantibodies against HLA-DRA in rheumatoid arthritis: association with disease progression*

**作者**:Smith A, et al.

**摘要**:该研究在类风湿性关节炎(RA)患者血清中检测到抗HLA-DRA的自身抗体,发现其与疾病活动性评分(DAS28)呈正相关,提示其可能作为RA预后标志物。

2. **文献名称**:*HLA-DRA-specific monoclonal antibody enhances antigen presentation in dendritic cells*

**作者**:Chen L, et al.

**摘要**:研究团队开发了一种靶向HLA-DRA的单克隆抗体,证实其可增强树突状细胞的抗原呈递能力,为肿瘤免疫治疗提供了潜在策略。

3. **文献名称**:*HLA-DRA antibody-mediated immune regulation in systemic lupus erythematosus*

**作者**:Wang Y, et al.

**摘要**:该研究发现系统性红斑狼疮(SLE)患者中HLA-DRA抗体通过干扰CD4+ T细胞与B细胞间的相互作用,参与异常免疫调节,可能成为治疗靶点。

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注:以上内容为示例,实际文献需通过PubMed、Google Scholar等平台以关键词“HLA-DRA antibody”或“anti-HLA-DRA”检索。若需具体文献,可提供疾病背景或应用场景进一步筛选。

       

背景信息

The HLA-DRA antibody targets the alpha chain of the HLA-DR antigen, a major histocompatibility complex (MHC) class II molecule critical for adaptive immune responses. HLA-DRA, encoded by the HLA-DRA gene on chromosome 6. pairs with HLA-DRB chains to form heterodimers that present exogenous antigens to CD4+ T cells, initiating immune activation. Unlike HLA-DRB chains, HLA-DRA exhibits limited polymorphism, contributing to structural stability rather than antigen-binding specificity.

Antibodies against HLA-DRA are widely used in research to study MHC class II expression patterns in immune-related diseases. Dysregulated HLA-DR expression is implicated in autoimmune disorders (e.g., rheumatoid arthritis, lupus), infections, and cancers. For example, reduced HLA-DR on antigen-presenting cells may correlate with immunosuppression in sepsis or tumor microenvironments. Conversely, overexpression is linked to autoimmune inflammation.

These antibodies enable detection via techniques like flow cytometry, immunohistochemistry, or Western blot, aiding in diagnostics and mechanistic studies. They also help explore HLA-DRA's role in transplant rejection, as MHC class II mismatches drive donor-specific immune responses. Additionally, HLA-DRA antibodies are tools for investigating transcriptional regulation of MHC genes, such as CIITA-mediated pathways. Their applications extend to therapeutic development, including checkpoint inhibitors or vaccines targeting HLA-DR-restricted antigens.

       
关键字: HLA-DRA抗体;HLA-DRA;HLA-DRA Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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