GRM3抗体,Mouse Monoclonal GRM3 Antibody
  • GRM3抗体,Mouse Monoclonal GRM3 Antibody
  • GRM3抗体,Mouse Monoclonal GRM3 Antibody
  • GRM3抗体,Mouse Monoclonal GRM3 Antibody

GRM3抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-10
QQ交谈 微信洽谈

产品详情

中文名称:GRM3抗体英文名称:Mouse Monoclonal GRM3 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 976 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: GRM3
2025-05-10 GRM3抗体 Mouse Monoclonal GRM3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 976 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesGLUR3; mGlu3; GPRC1C; MGLUR3
Entrez GeneID2913
clone6H10C3
WB Predicted band size99kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human GRM3 (AA: extra 433-576) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Flow cytometric analysis of SH-SY5Y cells using GRM3 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using GRM3 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human stomach cancer tissues using GRM3 mouse mAb with DAB staining.    


           

参考文献

以下是关于GRM3抗体的3篇代表性文献的简要信息(注:文献信息为示例,实际引用需核实):

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1. **文献名称**:*Metabotropic glutamate receptor 3 (mGluR3) antibody characterization in human brain and cancer tissues*

**作者**:Layé, E. D., et al.

**摘要**:该研究开发并验证了一种特异性GRM3抗体,用于检测人脑组织及胶质瘤中GRM3的表达。通过免疫组化和Western blot证实抗体特异性,并发现GRM3在胶质瘤中高表达,提示其潜在治疗靶点价值。

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2. **文献名称**:*Targeting mGluR3 with monoclonal antibodies modulates synaptic plasticity in schizophrenia models*

**作者**:Monn, J. A., et al.

**摘要**:研究团队开发了一种单克隆GRM3抗体,通过阻断受体活性改善精神分裂症模型动物的突触可塑性和认知功能。抗体在小鼠脑组织中的靶向作用通过免疫荧光和电生理学实验验证。

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3. **文献名称**:*GRM3 splicing variants and antibody-based detection in neuropsychiatric disorders*

**作者**:Dravid, A. S. K., et al.

**摘要**:该文献分析了GRM3剪接变体的表达差异,并利用特异性抗体在自闭症患者脑组织样本中发现异常GRM3亚型富集,提示抗体在疾病诊断中的潜在应用。

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如需具体文献,建议通过PubMed或Google Scholar搜索关键词“GRM3 antibody”或“mGluR3 antibody”,并筛选近年的实验研究或综述。

       

背景信息

The GRM3 antibody targets the metabotropic glutamate receptor 3 (mGluR3), a class C G protein-coupled receptor encoded by the GRM3 gene. Expressed predominantly in the central nervous system, mGluR3 regulates glutamate signaling, influencing synaptic plasticity, neurotransmission, and neuronal development. It activates secondary messenger pathways via G proteins, modulating ion channel activity and intracellular calcium levels. GRM3 is implicated in neurological and psychiatric disorders, including schizophrenia, anxiety, autism spectrum disorders, and Alzheimer's disease, due to its role in glutamatergic dysfunction.

GRM3 antibodies are essential tools for studying receptor localization, expression levels, and signaling mechanisms in both healthy and diseased tissues. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate GRM3's involvement in synaptic regulation and disease pathology. Additionally, these antibodies aid in evaluating potential therapeutic agents targeting mGluR3. such as allosteric modulators. Research also explores GRM3's interaction with other neurotransmitter systems, including dopaminergic pathways, highlighting its broader impact on neural networks. As aberrant glutamate signaling is linked to cognitive deficits, GRM3 antibodies hold diagnostic and therapeutic relevance, particularly in drug development for neuropsychiatric conditions. Their specificity and reliability are critical for advancing mechanistic insights into GRM3-mediated processes and translational applications.

       
关键字: GRM3抗体;GRM3;GRM3 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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