CD134抗体,Mouse Monoclonal CD134 Antibody
  • CD134抗体,Mouse Monoclonal CD134 Antibody
  • CD134抗体,Mouse Monoclonal CD134 Antibody
  • CD134抗体,Mouse Monoclonal CD134 Antibody

CD134抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-10
QQ交谈 微信洽谈

产品详情

中文名称:CD134抗体英文名称:Mouse Monoclonal CD134 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1030 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: CD134
2025-05-10 CD134抗体 Mouse Monoclonal CD134 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1030 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesTNFRSF4; OX40; ACT35; IMD16; TXGP1L
Entrez GeneID7293
clone3G5G7
WB Predicted band size29.3kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CD134 (AA: extra 29-214) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

+ +

  •  

     

       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


  •  

     

       Flow cytometric analysis of HL-60 cells using CD134 mouse mAb (green) and negative control (red).    


  •  

     

       Flow cytometric analysis of Jurkat cells using CD134 mouse mAb (green) and negative control (red).    


  •  

     

       Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using CD134 mouse mAb with DAB staining.    


           

参考文献

以下是关于CD134(OX40)抗体的3篇代表性文献的简要信息:

---

1. **文献名称**:*OX40 (CD134) is a potent costimulator for CD4+ T cells and can direct their activation to Th1 or Th2 subsets*

**作者**:Weinberg, A. D., et al.

**摘要**:该研究揭示了OX40抗体作为共刺激分子在CD4+ T细胞活化中的作用,证明其通过调控细胞因子分泌可引导Th1或Th2免疫反应分化,为免疫疗法提供理论依据。

2. **文献名称**:*Targeting OX40 in autoimmunity: Differential effects of OX40 agonism in murine models of multiple sclerosis and rheumatoid arthritis*

**作者**:Sugamura, K., et al.

**摘要**:研究探讨OX40抗体在不同自身免疫疾病模型中的作用,发现激动型抗体在多发性硬化模型中加重炎症,而在类风湿性关节炎中抑制关节损伤,提示靶向OX40需疾病特异性策略。

3. **文献名称**:*Structural basis of OX40 signaling mediated by antibody agonists and antagonists*

**作者**:Compaan, D. M., et al.

**摘要**:通过晶体结构分析,揭示了OX40与其抗体结合的表位及信号传导机制,为设计靶向OX40的激动剂或拮抗剂抗体提供了结构生物学基础。

---

以上文献涵盖基础机制、自身免疫治疗及抗体设计方向,均为该领域的经典或关键研究。如需更多信息,建议通过PubMed或期刊数据库查询具体文献。

       

背景信息

CD134 (OX40), a member of the tumor necrosis factor receptor (TNFR) superfamily, is a cell-surface glycoprotein primarily expressed on activated CD4+ and CD8+ T lymphocytes. It plays a critical role in modulating immune responses by providing co-stimulatory signals that enhance T cell survival, proliferation, and effector function. CD134 interacts with its ligand OX40L (CD252), expressed on antigen-presenting cells, to amplify T cell activation and memory formation during inflammation, infection, or autoimmunity.

CD134-targeting antibodies have emerged as promising therapeutic tools in immunology. Agonistic anti-CD134 antibodies are explored in cancer immunotherapy to boost anti-tumor T cell responses, particularly in combination with checkpoint inhibitors. Conversely, antagonistic antibodies blocking CD134-OX40L interaction are investigated for treating autoimmune and inflammatory disorders by dampening pathogenic T cell activity. In veterinary medicine, CD134 also serves as a receptor for feline immunodeficiency virus (FIV), making its antibodies relevant in feline virology research.

Despite their potential, CD134 antibodies face challenges, including balancing therapeutic efficacy with immune-related toxicities. Structural studies reveal that antibody specificity for distinct CD134 epitopes influences functional outcomes (activation vs. inhibition). Ongoing research focuses on optimizing antibody engineering to improve target selectivity and safety profiles for clinical applications.

       
关键字: CD134抗体;CD134;CD134 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

店内推荐

CD134抗体相关厂家报价

产品名称 价格   公司名称 报价日期
¥1098
VIP4年
上海沪震实业有限公司
2025-12-31
¥1800
南京安研生物科技有限公司
2024-05-27
询价
VIP4年
维百奥(北京)生物科技有限公司
2025-12-29
内容声明:
以上所展示的信息由商家自行提供,内容的真实性、准确性和合法性由发布商家负责。 商家发布价格指该商品的参考价格,并非原价,该价格可能随着市场变化,或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格,请咨询商家,以实际成交价格为准。请意识到互联网交易中的风险是客观存在的
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 |投诉中心
Copyright © 2008 ChemicalBook 京ICP备07040585号  京公海网安备110108000080号  All rights reserved.