LAMP2抗体

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human placenta tissue, Primary antibody: P00320(LAMP2 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P00320(LAMP2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P00320(LAMP2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

LAMP2 (Lysosomal-Associated Membrane Protein 2) is a key transmembrane glycoprotein predominantly located in lysosomal and late endosomal membranes. It belongs to the LAMP family, which includes LAMP1 and LAMP2. both critical for maintaining lysosomal structural integrity and function. LAMP2 consists of two domains: a heavily glycosylated luminal domain, which shields the lysosomal membrane from degradation, and a short cytoplasmic tail involved in intracellular trafficking and organelle interactions.

This protein plays multifaceted roles in autophagy, lysosomal enzyme activity regulation, and antigen presentation. Notably, LAMP2 is essential for autophagosome-lysosome fusion during autophagy, a cellular waste clearance process. Three splice variants (LAMP2A, LAMP2B, LAMP2C) exist, with LAMP2A specifically linked to chaperone-mediated autophagy.

Mutations in the LAMP2 gene are associated with Danon disease, a rare X-linked disorder characterized by cardiomyopathy, skeletal myopathy, and intellectual disability. LAMP2 antibodies are widely used in research to study lysosomal dynamics, autophagy-related mechanisms, and disease pathology. They also aid in diagnosing lysosomal storage disorders and monitoring protein expression in cancers or neurodegenerative diseases. Commercial LAMP2 antibodies typically target conserved regions of the luminal domain, enabling applications in Western blot, immunofluorescence, and immunohistochemistry.