GNA13抗体,Rabbit Polyclonal GNA13 Antibody
  • GNA13抗体,Rabbit Polyclonal GNA13 Antibody
  • GNA13抗体,Rabbit Polyclonal GNA13 Antibody
  • GNA13抗体,Rabbit Polyclonal GNA13 Antibody

GNA13抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-11
QQ交谈 微信洽谈

产品详情

中文名称:GNA13抗体英文名称:Rabbit Polyclonal GNA13 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1684 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: GNA13
2025-05-11 GNA13抗体 Rabbit Polyclonal GNA13 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1684 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesG13
WB Predicted band size44 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human GNA13
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 15%SDS-PAGE, Lysate: 40 μg, Lane 1-5: A172 cells, 293T cells, mouse kidney tissue, human testis tissue, Human brain malignant glioma tissue, Primary antibody: P00385(GNA13 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P00385(GNA13 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P00385(GNA13 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于GNA13抗体的3篇参考文献示例(注:文献信息为模拟,实际引用需核实):

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1. **文献名称**: *GNA13 promotes tumor cell invasion and metastasis in colorectal cancer via activation of RhoA signaling*

**作者**: Shi, Y., Chen, L., & Zhou, J.

**摘要**: 本研究探讨了GNA13在结直肠癌转移中的作用,利用特异性GNA13抗体进行Western blot和免疫组化分析。结果显示,GNA13通过激活RhoA信号通路增强肿瘤细胞侵袭能力,提示其作为转移抑制潜在靶点。

2. **文献名称**: *GNA13 regulates epithelial-mesenchymal transition in breast cancer through YAP/TAZ activation*

**作者**: Chen, X., Wang, H., & Liu, Q.

**摘要**: 通过免疫沉淀(使用GNA13抗体)和基因敲除实验,研究发现GNA13通过调控YAP/TAZ通路促进乳腺癌细胞的EMT过程,揭示了其在肿瘤微环境重塑中的关键机制。

3. **文献名称**: *Antibody-based validation of GNA13 as a therapeutic target in hepatocellular carcinoma*

**作者**: Zhang, R., Li, M., & Gao, S.

**摘要**: 该研究开发并验证了一种高特异性GNA13抗体,用于肝细胞癌组织芯片分析。结果显示GNA13高表达与患者预后不良相关,为靶向治疗提供了实验依据。

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**备注**:以上文献信息为示例,实际研究中请通过PubMed、Web of Science等平台检索真实文献,并核对作者、期刊及摘要内容。

       

背景信息

**Background of GNA13 Antibody**

GNA13 (Guanine Nucleotide-Binding Protein Subunit Alpha-13) is a member of the Gα12/13 subfamily of heterotrimeric G-protein alpha subunits, which play critical roles in transmitting signals from G-protein-coupled receptors (GPCRs) to intracellular effector pathways. GNA13 is involved in regulating diverse cellular processes, including cell proliferation, migration, cytoskeletal reorganization, and apoptosis, primarily through activation of Rho GTPase signaling pathways such as RhoA. Dysregulation of GNA13 has been implicated in cancer progression, cardiovascular diseases, and immune disorders, with studies linking its overexpression or hyperactivation to enhanced tumor invasiveness, metastasis, and poor clinical outcomes.

GNA13 antibodies are essential tools for investigating the expression, localization, and functional roles of GNA13 in both physiological and pathological contexts. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and co-immunoprecipitation (Co-IP) to study protein levels, tissue distribution, and interaction partners. Specificity is a key consideration, as GNA13 shares homology with other Gα subunits (e.g., GNA12), necessitating rigorous validation via knockout controls or siRNA-based silencing. Some antibodies target unique epitopes within conserved domains, such as the GTP-binding region or C-terminal tail, to ensure precise detection.

Research utilizing GNA13 antibodies has advanced understanding of its role in diseases and highlighted its potential as a therapeutic target, particularly in cancers with aberrant GPCR-Rho signaling. Reliable antibodies remain crucial for unraveling the complex mechanisms governed by GNA13 in health and disease.

       
关键字: GNA13抗体;GNA13;GNA13 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (3年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
普通会员
  • 公司成立:3年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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