UGCG抗体,Rabbit Polyclonal UGCG Antibody
  • UGCG抗体,Rabbit Polyclonal UGCG Antibody
  • UGCG抗体,Rabbit Polyclonal UGCG Antibody
  • UGCG抗体,Rabbit Polyclonal UGCG Antibody

UGCG抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-11
QQ交谈 微信洽谈

产品详情

中文名称:UGCG抗体英文名称:Rabbit Polyclonal UGCG Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1689 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: UGCG
2025-05-11 UGCG抗体 Rabbit Polyclonal UGCG Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1689 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesGCS; GLCT1
WB Predicted band size45 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human UGCG
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Mouse brain tissue, MCF7, A375 cell lysates, Primary antibody: P00397(UGCG Antibody) at dilution 1/1350, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P00397(UGCG Antibody) at dilution 1/95. (Original magnification: ×200)    


           

参考文献

以下是3篇涉及UGCG抗体的相关文献摘要(基于公开研究整理,部分为虚构示例供参考):

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1. **"UGCG knockdown inhibits glioblastoma growth through ceramide accumulation"**

*作者:Smith A, et al. (2020)*

*摘要:* 本研究利用UGCG特异性抗体(货号ABX-123)通过Western blot验证了shRNA敲低UGCG在胶质母细胞瘤细胞中的效率,发现抑制UGCG导致神经酰胺水平上升并诱导肿瘤细胞凋亡。

2. **"Anti-UGCG monoclonal antibody blocks glycosphingolipid synthesis in Gaucher disease models"**

*作者:Chen L, et al. (2018)*

*摘要:* 开发了一种靶向UGCG的单克隆抗体(克隆号mAb-5C2),通过免疫荧光和流式细胞术证实其可抑制UGCG酶活性,减少葡糖神经酰胺合成,为戈谢病治疗提供新策略。

3. **"UGCG overexpression promotes chemoresistance via antibody-based detection in colorectal cancer"**

*作者:Wang Y, et al. (2022)*

*摘要:* 使用兔源多克隆UGCG抗体(Sigma-Aldrich HPA042772)进行免疫组化分析,发现结直肠癌中UGCG高表达与奥沙利铂耐药性相关,机制涉及鞘脂代谢重编程。

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注:以上文献为示例性质,实际引用需以真实数据库(如PubMed)检索结果为准。建议通过关键词“UGCG antibody”、“glucosylceramide synthase”等结合实验方法(如Western blot/IHC)筛选目标文献。

       

背景信息

The UDP-glucose ceramide glucosyltransferase (UGCG) antibody is a crucial tool for studying the enzyme UGCG, a key regulator in glycosphingolipid (GSL) biosynthesis. UGCG catalyzes the transfer of glucose to ceramide, forming glucosylceramide (GlcCer), the foundational step in GSL synthesis. These lipids are essential components of cell membranes, influencing signal transduction, cell adhesion, and membrane trafficking. Dysregulation of UGCG activity is linked to pathological conditions, including cancer, neurodegenerative diseases, and lysosomal storage disorders like Gaucher’s disease.

In cancer research, UGCG overexpression is associated with multidrug resistance and tumor progression, as GSLs modulate survival pathways and drug efflux mechanisms. UGCG antibodies enable detection of enzyme expression levels in tissues or cell lines, aiding mechanistic studies. In neuroscience, altered GSL metabolism due to UGCG dysfunction is implicated in Parkinson’s and Alzheimer’s diseases. Additionally, UGCG inhibitors are explored as therapeutic agents, necessitating precise antibody-based quantification in preclinical models.

UGCG antibodies are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry. Their specificity is validated via knockout controls or enzymatic assays. Research also focuses on UGCG’s role in viral entry mechanisms, as certain viruses exploit GSL-rich membrane domains for infection. Understanding UGCG’s biological and pathological roles underscores the antibody’s importance in both basic science and translational applications.

       
关键字: UGCG抗体;UGCG;UGCG Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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