PRPH抗体,Rabbit Polyclonal PRPH Antibody
  • PRPH抗体,Rabbit Polyclonal PRPH Antibody
  • PRPH抗体,Rabbit Polyclonal PRPH Antibody
  • PRPH抗体,Rabbit Polyclonal PRPH Antibody

PRPH抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-11
QQ交谈 微信洽谈

产品详情

中文名称:PRPH抗体英文名称:Rabbit Polyclonal PRPH Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1737 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: PRPH
2025-05-11 PRPH抗体 Rabbit Polyclonal PRPH Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1737 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/500-1/1000 Human,Mouse,Rat
   

产品详情

AliasesNEF4; PRPH1
WB Predicted band size54 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human PRPH
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: TM4 cell lysate, Primary antibody: P00622(PRPH Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 9 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P00622(PRPH Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P00622(PRPH Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于PRPH(Peripherin)抗体的3篇代表性文献摘要:

1. **文献名称**:*Autoantibodies to peripherin in patients with autoimmune neuropathy*

**作者**:Yan WX, et al.

**摘要**:研究发现PRPH抗体可能与自身免疫性神经病变相关,患者血清中检测到抗peripherin抗体,提示其可能参与周围神经轴突损伤的免疫机制。

2. **文献名称**:*Peripherin as a biomarker for amyotrophic lateral sclerosis*

**作者**:Robertson J, et al.

**摘要**:探讨peripherin在肌萎缩侧索硬化症(ALS)中的异常聚集现象,研究发现PRPH抗体可特异性标记患者神经元中的病理蛋白沉积,提示其作为疾病生物标志物的潜力。

3. **文献名称**:*Differential expression of peripherin isoforms in neurological disorders*

**作者**:Larivière RC, et al.

**摘要**:分析PRPH不同异构体在神经退行性疾病中的表达差异,通过特异性抗体检测发现某些异构体在阿尔茨海默病和帕金森病中异常上调,可能与疾病进展相关。

注:以上文献为示例,实际引用需根据具体研究领域核实(如神经科学、自身免疫疾病等)。建议通过PubMed或Google Scholar以关键词"peripherin antibody"+"disease"检索最新研究。

       

背景信息

PRPH antibodies target peripherin, a type III intermediate filament protein primarily expressed in neurons of the peripheral nervous system (PNS) and subsets of central nervous system (CNS) neurons. Peripherin plays a structural role in maintaining neuronal integrity, axon outgrowth, and intracellular transport. Its dysregulation has been linked to neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and Charcot-Marie-Tooth neuropathy.

PRPH antibodies are of interest in both research and clinical contexts. In research, they serve as tools to study peripherin's function, localization, and interactions in neuronal health and disease. Clinically, anti-PRPH antibodies are occasionally detected in autoimmune neurological disorders, though their pathogenic role remains unclear. Some studies associate them with neuropathies or paraneoplastic syndromes, but their diagnostic specificity is limited.

Notably, peripherin exists in multiple splice variants, and PRPH antibodies may exhibit varying reactivity depending on isoforms. This complicates interpretations in disease models. Recent work explores peripherin aggregation in ALS, with PRPH antibodies aiding in detecting pathological inclusions. Challenges include distinguishing between antibodies generated experimentally and those arising spontaneously in autoimmune conditions. Further research is needed to clarify their clinical relevance and potential as biomarkers or therapeutic targets.

       
关键字: PRPH抗体;PRPH;PRPH Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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