CARD8抗体,Rabbit Polyclonal CARD8 Antibody
  • CARD8抗体,Rabbit Polyclonal CARD8 Antibody
  • CARD8抗体,Rabbit Polyclonal CARD8 Antibody
  • CARD8抗体,Rabbit Polyclonal CARD8 Antibody

CARD8抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-11
QQ交谈 微信洽谈

产品详情

中文名称:CARD8抗体英文名称:Rabbit Polyclonal CARD8 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1876 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: CARD8
2025-05-11 CARD8抗体 Rabbit Polyclonal CARD8 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1876 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesANF; ANP; PND; ATFB6; CDD-ANF
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human NPPA
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

  •  

     

       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08023(NPPA Antibody) at dilution 1/30. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P08023(NPPA Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于CARD8抗体的3篇代表性文献(虚拟示例,需根据实际文献验证):

1. **"CARD8 regulates NLRP3 inflammasome activation through caspase-1 interaction"**

- **作者**: Li Y et al.

- **摘要**: 研究揭示了CARD8通过结合caspase-1调控NLRP3炎症小体活化的分子机制,并开发了特异性抗体用于检测其在炎症反应中的表达变化。

2. **"Structural basis of CARD8 autoinhibition and its role in HIV protease sensing"**

- **作者**: Johnson RM et al.

- **摘要**: 利用CARD8抗体进行结构解析,阐明了CARD8的自抑制构象及其在识别HIV蛋白酶介导的细胞焦亡中的关键作用。

3. **"CARD8 expression correlates with cardiovascular disease progression"**

- **作者**: Wang H et al.

- **摘要**: 通过免疫组化分析(使用CARD8特异性抗体),发现CARD8在动脉粥样硬化患者血管组织中的表达上调,提示其与心血管炎症的潜在关联。

4. **"Antibody-based targeting of CARD8 for inflammatory disease therapy"**

- **作者**: Chen L et al.

- **摘要**: 开发了靶向CARD8的单克隆抗体,并在小鼠模型中验证其通过抑制过度炎症反应缓解类风湿性关节炎的疗效。

**注意**:以上文献标题及内容为示例性质,具体研究需查阅真实数据库(如PubMed、Google Scholar)。建议使用关键词“CARD8 antibody”或“CARD8 inflammasome”检索最新文献。

       

背景信息

CARD8 (Caspase activation and recruitment domain 8) is a protein involved in regulating inflammatory responses and apoptosis. It belongs to the CARD protein family, which mediates protein-protein interactions through its conserved CARD domain. Structurally, CARD8 contains an N-terminal pyrin domain (PYD), a central CARD domain, and a C-terminal inhibitory domain that undergoes proteasomal degradation under specific conditions. This degradation releases the N-terminal fragment, enabling its role in inflammasome activation. CARD8 interacts with NLRP3 inflammasome components and modulates caspase-1 activation, influencing the maturation of pro-inflammatory cytokines like IL-1β and IL-18.

CARD8 antibodies are research tools used to study its expression, localization, and molecular interactions in immune signaling pathways. Dysregulation of CARD8 has been implicated in autoimmune and inflammatory diseases, including rheumatoid arthritis, gout, and inflammatory bowel disease. Certain genetic polymorphisms in CARD8 are associated with altered disease susceptibility or severity, highlighting its potential as a biomarker. In therapeutic contexts, targeting CARD8 pathways may offer strategies to modulate aberrant inflammasome activity. However, its dual role in promoting or suppressing inflammation—depending on cellular context and proteolytic processing—complicates its functional characterization. Current studies employ CARD8 antibodies in techniques like Western blotting, immunofluorescence, and co-immunoprecipitation to unravel its mechanisms in health and disease. Further research is needed to clarify its tissue-specific functions and therapeutic potential.

       
关键字: CARD8抗体;CARD8;CARD8 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

店内推荐

CARD8抗体相关厂家报价

产品名称 价格   公司名称 报价日期
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
¥960.00
VIP10年
北京索莱宝科技有限公司
2025-12-30
询价
VIP5年
上海冠导生物工程有限公司
2025-12-30
内容声明:
以上所展示的信息由商家自行提供,内容的真实性、准确性和合法性由发布商家负责。 商家发布价格指该商品的参考价格,并非原价,该价格可能随着市场变化,或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格,请咨询商家,以实际成交价格为准。请意识到互联网交易中的风险是客观存在的
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 |投诉中心
Copyright © 2008 ChemicalBook 京ICP备07040585号  京公海网安备110108000080号  All rights reserved.