CYP4A11抗体,Rabbit Polyclonal CYP4A11 Antibody
  • CYP4A11抗体,Rabbit Polyclonal CYP4A11 Antibody
  • CYP4A11抗体,Rabbit Polyclonal CYP4A11 Antibody
  • CYP4A11抗体,Rabbit Polyclonal CYP4A11 Antibody

CYP4A11抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-11
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产品详情

中文名称:CYP4A11抗体英文名称:Rabbit Polyclonal CYP4A11 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1907 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: CYP4A11
2025-05-11 CYP4A11抗体 Rabbit Polyclonal CYP4A11 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1907 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesCP4Y; CYP4A2; CYP4AII; CYPIVA11
WB Predicted band size59 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human CYP4A11
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A431 cell lysate, Primary antibody: P01260(CYP4A11 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P01260(CYP4A11 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P01260(CYP4A11 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于CYP4A11抗体的3篇模拟参考文献(基于已有研究的合理虚构示例):

1. **文献名称**:*"Characterization of CYP4A11 antibody specificity in human renal tissues"*

**作者**:Johnson R, et al.

**摘要**:本研究验证了一种针对CYP4A11蛋白的单克隆抗体的特异性,通过Western blot和免疫组化技术证实其在人肾脏组织中的选择性表达,并发现CYP4A11在肾小管上皮细胞中高表达,可能与高血压相关代谢通路有关。

2. **文献名称**:*"Role of CYP4A11 in vascular dysfunction: Insights from antibody-based inhibition studies"*

**作者**:Lee S, et al.

**摘要**:利用CYP4A11特异性抗体阻断其活性,研究显示该酶通过调节20-HETE(20-羟基二十碳四烯酸)的合成影响血管张力,提示CYP4A11可能成为治疗心血管疾病的潜在靶点。

3. **文献名称**:*"Development of a polyclonal antibody for CYP4A11 and its application in hepatocellular carcinoma"*

**作者**:Zhang Y, et al.

**摘要**:开发了一种兔源多克隆抗体,用于检测肝细胞癌(HCC)中CYP4A11的表达水平。研究发现,CYP4A11在HCC组织中显著下调,可能通过脂质代谢重编程影响肿瘤进展。

(注:以上文献为模拟示例,实际引用时需检索真实数据库如PubMed获取准确信息。)

       

背景信息

The CYP4A11 antibody is a tool used to detect and study the cytochrome P450 family 4 subfamily A member 11 (CYP4A11), an enzyme critical in fatty acid metabolism. CYP4A11. primarily expressed in the kidney and liver, catalyzes the hydroxylation of medium-chain fatty acids, such as arachidonic acid, to produce 20-hydroxyeicosatetraenoic acid (20-HETE). This metabolite plays a key role in regulating vascular tone, blood pressure, and renal tubular ion transport. Dysregulation of CYP4A11 activity or expression has been linked to hypertension, cardiovascular diseases, and metabolic disorders.

Researchers utilize CYP4A11 antibodies in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to analyze its tissue distribution, expression levels, and interactions in both normal and pathological states. These antibodies are often developed in rabbits or mice, targeting specific epitopes of the human CYP4A11 protein. Studies employing these reagents have explored genetic polymorphisms (e.g., the T8590C variant) associated with altered enzyme activity and disease susceptibility. Additionally, CYP4A11 antibodies aid in investigating its role in drug metabolism and potential as a therapeutic target. Their specificity and reliability are validated through knockdown controls or recombinant protein assays to ensure accurate detection in complex biological samples.

       
关键字: CYP4A11抗体;CYP4A11;CYP4A11 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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