UGT2B4抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue lysate, Primary antibody: P01981(UGT2B4 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P01981(UGT2B4 Antibody) at dilution 1/140. (Original magnification: ×200)    

  
  

The UDP-glucuronosyltransferase 2B4 (UGT2B4) enzyme, part of the UGT superfamily, plays a critical role in phase II metabolism by conjugating glucuronic acid to endogenous compounds (e.g., bile acids, steroid hormones) and xenobiotics, enhancing their solubility for excretion. UGT2B4 is predominantly expressed in the liver, gastrointestinal tract, and steroid-responsive tissues, with genetic polymorphisms influencing enzyme activity and interindividual variability in drug metabolism and disease susceptibility.

UGT2B4-specific antibodies are essential tools for studying its expression, localization, and function in physiological and pathological contexts. These antibodies enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding research on UGT2B4's role in hormone regulation, detoxification, and cancer progression (e.g., hormone-dependent cancers). Dysregulation of UGT2B4 has been linked to metabolic disorders, cholestasis, and resistance to therapies targeting steroid signaling. Commercially available antibodies are typically developed in rabbits or mice, targeting epitopes within the enzyme's variable substrate-binding regions. Validation includes specificity testing using knockout models or siRNA-mediated silencing. Reliable UGT2B4 antibodies are crucial for advancing pharmacokinetic studies, biomarker discovery, and personalized medicine approaches.