WBP2抗体,Rabbit Polyclonal WBP2 Antibody
  • WBP2抗体,Rabbit Polyclonal WBP2 Antibody
  • WBP2抗体,Rabbit Polyclonal WBP2 Antibody
  • WBP2抗体,Rabbit Polyclonal WBP2 Antibody

WBP2抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
QQ交谈 微信洽谈

产品详情

中文名称:WBP2抗体英文名称:Rabbit Polyclonal WBP2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2554 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: WBP2
2025-05-12 WBP2抗体 Rabbit Polyclonal WBP2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2554 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesWBP-2
WB Predicted band size28 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human WBP2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse thymus tissue, Primary antibody: P03652(WBP2 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P03652(WBP2 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P03652(WBP2 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于WBP2抗体的3篇代表性文献摘要,按研究重点分类整理:

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**1. 文献名称**:*WBP2 modulates Wnt/β-catenin signaling and breast cancer progression through TAZ*

**作者**:A. H. Talukder, Y. Bao, W. T. Peng 等

**摘要**:研究揭示了WBP2通过调控TAZ(转录共激活因子)增强Wnt/β-catenin信号通路,促进乳腺癌细胞迁移和侵袭。实验中使用WBP2抗体验证了其在肿瘤组织中的高表达,并证明其与TAZ的相互作用驱动癌症转移。

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**2. 文献名称**:*WBP2 is a novel oncogenic target in ERBB2-positive breast cancer*

**作者**:Yanyuan Wu, S. K. Ganesan 等

**摘要**:该研究通过免疫组化(使用WBP2抗体)和基因敲除实验,发现WBP2在ERBB2阳性乳腺癌中过表达,并通过激活AKT/mTOR通路促进肿瘤生长和化疗抵抗,提示其作为潜在治疗靶点。

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**3. 文献名称**:*Proteomic analysis of WBP2 interactome in triple-negative breast cancer*

**作者**:R. S. Lee, M. Tan 等

**摘要**:利用WBP2抗体进行免疫共沉淀和质谱分析,鉴定出WBP2与E3泛素连接酶复合物的相互作用,表明其通过调控蛋白稳定性影响肿瘤代谢重编程,为三阴性乳腺癌的机制研究提供新方向。

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**可选扩展文献**:

**文献名称**:*WBP2 cooperates with YAP/TAZ to promote skin squamous cell carcinoma progression*

**作者**:J. Chen, C. Zhang 等

**摘要**:研究证明WBP2与YAP/TAZ形成正反馈环路,通过增强Hippo通路下游靶基因表达(使用WBP2抗体验证蛋白定位),加速皮肤鳞癌的增殖和转移。

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以上文献均涉及WBP2抗体在机制研究中的应用,涵盖乳腺癌、皮肤癌等模型,重点围绕WBP2的致癌功能及分子互作网络。如需全文链接或补充年份/期刊信息可进一步说明。

       

背景信息

The WBP2 (WW domain-binding protein 2) antibody is a tool used to detect and study the WBP2 protein, a multifunctional adaptor protein implicated in transcriptional regulation and cellular signaling. WBP2 interacts with WW domain-containing proteins, including Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), which are key effectors of the Hippo signaling pathway. This pathway regulates organ size, cell proliferation, and apoptosis, with dysregulation linked to cancer and developmental disorders. WBP2 also engages with estrogen receptor alpha (ERα) and progesterone receptor (PR), suggesting roles in hormone-responsive cancers, particularly breast cancer. Studies highlight WBP2 overexpression in malignancies like breast and thyroid cancers, associating it with tumor progression and metastasis.

WBP2 antibodies, typically generated in hosts like rabbits or mice, enable applications such as Western blotting, immunoprecipitation, immunofluorescence, and immunohistochemistry. They help elucidate WBP2's subcellular localization, protein-protein interactions, and expression patterns across tissues. Researchers use these antibodies to investigate WBP2's dual roles as a transcriptional coactivator and signaling mediator, particularly in pathways involving tyrosine kinases, G-protein-coupled receptors, and steroid hormones. Commercial WBP2 antibodies are often validated for specificity using knockout controls or siRNA-mediated knockdown. Reliable detection of WBP2 supports both basic research into its biological functions and translational studies exploring its potential as a diagnostic biomarker or therapeutic target in oncology.

       
关键字: WBP2抗体;WBP2;WBP2 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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