AVPR2抗体

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P03776(AVPR2 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P03776(AVPR2 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The arginine vasopressin receptor type 2 (AVPR2) is a G protein-coupled receptor (GPCR) primarily expressed in the renal collecting duct cells. It plays a critical role in regulating water homeostasis by mediating the antidiuretic effects of arginine vasopressin (AVP). Upon AVP binding, AVPR2 activates the Gs-adenylyl cyclase-cAMP pathway, triggering the insertion of aquaporin-2 (AQP2) water channels into the apical membrane, enabling water reabsorption. Dysregulation of AVPR2 is linked to X-linked nephrogenic diabetes insipidus (NDI), a condition characterized by impaired urinary concentrating ability due to mutations in the AVPR2 gene.

AVPR2 antibodies are essential tools for studying receptor expression, localization, and function. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry to detect AVPR2 in tissues or cultured cells. Researchers employ these antibodies to investigate AVPR2-related pathologies, including NDI, or to explore its role in disorders involving fluid imbalance, such as heart failure and hypertension. Additionally, AVPR2 antibodies aid in drug development targeting water retention disorders or AVP signaling pathways. Specificity and validation (e.g., knockout controls) are crucial for ensuring reliable results, as cross-reactivity with other GPCRs may occur. Commercial AVPR2 antibodies are typically raised against epitopes in extracellular or intracellular domains, with applications spanning basic research and clinical diagnostics.