E2F4抗体

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P03881(E2F4 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P03881(E2F4 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The E2F4 antibody is a crucial tool for studying the E2F family of transcription factors, which play pivotal roles in cell cycle regulation, differentiation, and apoptosis. E2F4. a member of the E2F family, primarily functions as a transcriptional repressor by forming complexes with retinoblastoma-like proteins (e.g., p130 or p107) and chromatin-modifying enzymes to silence target genes during quiescence or terminal differentiation. Unlike other E2F members, E2F4 is predominantly cytoplasmic but translocates to the nucleus to regulate gene expression in response to specific signals. Its involvement in cell cycle exit and maintenance of cellular homeostasis makes it a focus in cancer research, as dysregulation of E2F4 is linked to tumor progression and chemoresistance.

The E2F4 antibody is widely used in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to detect protein expression, subcellular localization, and DNA-binding activity. It is typically raised in hosts such as rabbits or mice, targeting specific epitopes or post-translational modifications of E2F4. Validated for specificity and sensitivity, this antibody aids in exploring E2F4’s role in development, senescence, and diseases. Researchers rely on it to dissect mechanisms of transcriptional repression, cell cycle arrest, and tumor suppression, making it indispensable in molecular and cancer biology studies.