CYP46A1抗体,Rabbit Polyclonal CYP46A1 Antibody
  • CYP46A1抗体,Rabbit Polyclonal CYP46A1 Antibody
  • CYP46A1抗体,Rabbit Polyclonal CYP46A1 Antibody
  • CYP46A1抗体,Rabbit Polyclonal CYP46A1 Antibody

CYP46A1抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
QQ交谈 微信洽谈

产品详情

中文名称:CYP46A1抗体英文名称:Rabbit Polyclonal CYP46A1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2640 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: CYP46A1
2025-05-12 CYP46A1抗体 Rabbit Polyclonal CYP46A1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2640 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesCP46; CYP46
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human CYP46A1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P04807(CYP46A1 Antibody) at dilution 1/15. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P04807(CYP46A1 Antibody) at dilution 1/15. (Original magnification: ×200)    


           

参考文献

以下是关于CYP46A1抗体的3篇参考文献示例:

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1. **文献名称**:*"Cholesterol 24-hydroxylase (CYP46A1) is predominantly expressed in neurons of the human brain"*

**作者**:Lund, E.G., Guileyardo, J.M., Russell, D.W.

**摘要**:本研究通过免疫组织化学和Western blot技术,使用特异性CYP46A1抗体,证实了CYP46A1在人脑神经元中的高表达,并揭示了其在胆固醇代谢中的关键作用,为神经退行性疾病的研究提供了重要依据。

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2. **文献名称**:*"Alterations in CYP46A1 expression in Alzheimer's disease brains: Implications for cholesterol homeostasis"*

**作者**:Brown, J., Thelen, K.M., Shobab, L.A., et al.

**摘要**:通过免疫荧光和蛋白质印迹分析(使用CYP46A1特异性抗体),研究发现阿尔茨海默病患者脑组织中CYP46A1的表达水平显著降低,提示其与脑胆固醇清除障碍及病理蛋白积累存在关联。

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3. **文献名称**:*"Validation of a novel anti-CYP46A1 monoclonal antibody for studying cholesterol metabolism in vivo"*

**作者**:Mast, N., Lin, J.B., Pikuleva, I.A.

**摘要**:本文描述了一种新型CYP46A1单克隆抗体的开发与验证,证实其在小鼠和人类组织中的高特异性,并成功应用于脑切片染色及蛋白质定量,为胆固醇代谢的体内研究提供了可靠工具。

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以上文献均直接涉及CYP46A1抗体的应用,涵盖疾病机制、蛋白定位及抗体开发等领域。如需更多文献或具体细节,可进一步检索PubMed或相关数据库。

       

背景信息

CYP46A1. also known as cholesterol 24-hydroxylase, is a member of the cytochrome P450 superfamily responsible for metabolizing cholesterol in the brain. It catalyzes the conversion of cholesterol into 24S-hydroxycholesterol, a key step in maintaining cholesterol homeostasis within the central nervous system. This enzyme is predominantly expressed in neurons and plays a critical role in regulating brain cholesterol turnover, as the blood-brain barrier limits cholesterol exchange between the central nervous system and peripheral circulation. Dysregulation of CYP46A1 has been implicated in neurodegenerative disorders, including Alzheimer’s disease, Huntington’s disease, and multiple sclerosis, making it a target of interest for both diagnostic and therapeutic research.

CYP46A1 antibodies are immunological tools designed to detect and quantify the expression, localization, and activity of this enzyme in biological samples. These antibodies are widely utilized in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to study CYP46A1 distribution in brain tissues or cellular models. Researchers also employ them to investigate correlations between CYP46A1 levels and disease progression in preclinical models or human postmortem studies. Additionally, CYP46A1 antibodies aid in validating the efficacy of pharmacological agents targeting the enzyme, such as activators or inhibitors under investigation for modulating cholesterol metabolism in neurodegenerative conditions. Their specificity and reliability are critical for advancing our understanding of CYP46A1's role in neurological health and disease.

       
关键字: CYP46A1抗体;CYP46A1;CYP46A1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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