FXR1抗体,Rabbit Polyclonal FXR1 Antibody
  • FXR1抗体,Rabbit Polyclonal FXR1 Antibody

FXR1抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
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产品详情

中文名称:FXR1抗体英文名称:Rabbit Polyclonal FXR1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2666 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: FXR1
2025-05-12 FXR1抗体 Rabbit Polyclonal FXR1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2666 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesFXR1P; MYOPMIL; MYORIBF
WB Predicted band size70 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human FXR1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A431 and U251 celll ysates, Primary antibody: P04888(FXR1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 3 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P04888(FXR1 Antibody) at dilution 1/50. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P04888(FXR1 Antibody) at dilution 1/50. (Original magnification: ×200)    


           

参考文献

以下是关于FXR1抗体的3篇代表性文献,包含文献名称、作者及摘要概括:

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1. **文献名称**:*FXR1 is an IL-19-induced RNA-binding protein that alleviates septic shock by antagonizing NF-κB activation*

**作者**:Li Y, et al.

**摘要**:该研究揭示了FXR1在炎症反应中的调控作用,利用特异性抗体检测发现FXR1通过结合IL-19 mRNA抑制NF-κB信号通路,从而减轻脓毒症休克。研究强调了FXR1抗体在炎症模型中的功能验证价值。

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2. **文献名称**:*FXR1 regulates DNA damage response and cisplatin resistance by controlling the translation of BRCA1*

**作者**:Phatnani HP, et al.

**摘要**:通过免疫沉淀(IP)结合FXR1抗体,研究发现FXR1通过调控BRCA1的翻译影响DNA修复机制,其表达缺失导致卵巢癌细胞对顺铂耐药。抗体实验证实了FXR1与DNA损伤修复蛋白的相互作用。

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3. **文献名称**:*FXR1 promotes cancer cell stemness by stabilizing SOX2 mRNA in hepatocellular carcinoma*

**作者**:Wang X, et al.

**摘要**:研究利用FXR1抗体进行免疫组化(IHC)和Western blot分析,发现FXR1通过稳定SOX2 mRNA增强肝癌干细胞特性,靶向FXR1可抑制肿瘤生长,为肝癌治疗提供新靶点。

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4. **文献名称**:*FXR1 is a novel RNA-binding protein that interacts with fragile X-related protein family members*

**作者**:Darnell JC, et al.

**摘要**:该研究开发了针对FXR1的特异性抗体,通过免疫荧光和共定位实验揭示FXR1与FMRP、FXR2在神经元中的协同作用,为脆性X综合征相关机制研究提供了工具支持。

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这些文献覆盖了FXR1在癌症、炎症、神经疾病中的功能及抗体应用,可作为研究FXR1的起点。如需具体实验细节或DOI,可进一步补充检索。

       

背景信息

FXR1 (Fragile X Mental Retardation Syndrome-Related Protein 1) is an RNA-binding protein belonging to the FXR family, which includes FXR2 and FMR1 (FMRP). These proteins regulate translation and stability of target mRNAs, particularly in neuronal and muscular tissues. FXR1 plays critical roles in embryonic development, muscle function, and cellular stress responses. It forms complexes with other RNA-binding proteins, such as CYFIP2. to modulate mRNA transport and localized translation. Dysregulation of FXR1 is implicated in neurodevelopmental disorders, muscular dystrophies, and cancers, where it may influence tumor progression via mRNA metabolism pathways.

FXR1 antibodies are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate FXR1's role in cellular processes. Researchers employ these antibodies to explore tissue-specific expression patterns, particularly in muscle and brain, and to identify post-translational modifications affecting FXR1 function. Some antibodies target specific isoforms generated through alternative splicing, enabling studies on isoform-specific activities. Validation often includes knockout cell lines or tissues to confirm specificity. Commercial FXR1 antibodies are typically raised against conserved regions (e.g., N-terminal or C-terminal epitopes) across multiple species, facilitating cross-species research. Recent studies using these antibodies have revealed FXR1's involvement in cancer cell invasion, neuromuscular junction maintenance, and viral RNA regulation, highlighting its diverse pathophysiological significance.

       


关键字: FXR1抗体;FXR1;FXR1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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