HMGCS1抗体,Rabbit Polyclonal HMGCS1 Antibody
  • HMGCS1抗体,Rabbit Polyclonal HMGCS1 Antibody
  • HMGCS1抗体,Rabbit Polyclonal HMGCS1 Antibody
  • HMGCS1抗体,Rabbit Polyclonal HMGCS1 Antibody

HMGCS1抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
QQ交谈 微信洽谈

产品详情

中文名称:HMGCS1抗体英文名称:Rabbit Polyclonal HMGCS1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2684 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: HMGCS1
2025-05-12 HMGCS1抗体 Rabbit Polyclonal HMGCS1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2684 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesHMGCS
WB Predicted band size57 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human HMGCS1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal liver tissue, Primary antibody: P04931(HMGCS1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P04931(HMGCS1 Antibody) at dilution 1/40. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P04931(HMGCS1 Antibody) at dilution 1/40. (Original magnification: ×200)    


           

参考文献

以下是关于HMGCS1抗体的3篇示例参考文献(内容为模拟示例,仅供参考):

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1. **文献名称**: *HMGCS1-mediated ketogenesis promotes hepatocellular carcinoma progression*

**作者**: Li et al., 2020

**摘要**: 研究通过Western blot和免疫组化(使用HMGCS1抗体)发现,HMGCS1在肝癌组织中高表达,其介导的酮体生成通过调控能量代谢促进肿瘤生长,提示其作为潜在治疗靶点。

2. **文献名称**: *HMGCS1 regulates lipid metabolism in glioblastoma via the AMPK pathway*

**作者**: Smith et al., 2018

**摘要**: 利用HMGCS1特异性抗体进行蛋白质定位分析,发现其在胶质母细胞瘤细胞线粒体中富集,并通过AMPK通路调控脂质代谢,影响肿瘤细胞存活。

3. **文献名称**: *Antibody-based profiling of HMGCS1 in ovarian cancer stem cells*

**作者**: Garcia-Ruiz et al., 2021

**摘要**: 研究通过流式细胞术和免疫荧光(基于HMGCS1单克隆抗体)证实HMGCS1在卵巢癌干细胞中高表达,与化疗耐药性和胆固醇合成异常相关。

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(注:以上为模拟生成的参考文献,实际文献需通过PubMed、Google Scholar等平台检索确认。)

       

背景信息

The HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1) antibody is a crucial tool for studying the enzyme HMGCS1. a rate-limiting mitochondrial protein involved in ketogenesis and cholesterol biosynthesis. HMGCS1 catalyzes the condensation of acetoacetyl-CoA and acetyl-CoA to form HMG-CoA, a key intermediate in these metabolic pathways. Dysregulation of HMGCS1 has been linked to metabolic disorders, cancers (e.g., hepatocellular carcinoma), and neurodegenerative diseases, making it a research focus in metabolism and disease mechanisms.

HMGCS1 antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect protein expression levels, subcellular localization, and tissue distribution. Their specificity is critical for distinguishing HMGCS1 from its cytosolic isoform HMGCS2. which functions in ketone body production during fasting. Validated antibodies help elucidate HMGCS1's role in cellular energy homeostasis, lipid metabolism, and disease progression.

Commercial HMGCS1 antibodies are typically raised against peptide sequences unique to the human or murine protein, with applications in both basic research and clinical studies. Their utility extends to exploring therapeutic strategies targeting cholesterol synthesis pathways, particularly in cancer and cardiovascular diseases. Proper validation using knockout controls or siRNA knockdown is essential to ensure antibody reliability in experimental models.

       
关键字: HMGCS1抗体;HMGCS1;HMGCS1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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