MAGEE1抗体,Rabbit Polyclonal MAGEE1 Antibody
  • MAGEE1抗体,Rabbit Polyclonal MAGEE1 Antibody
  • MAGEE1抗体,Rabbit Polyclonal MAGEE1 Antibody
  • MAGEE1抗体,Rabbit Polyclonal MAGEE1 Antibody

MAGEE1抗体 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
QQ交谈 微信洽谈

产品详情

中文名称:MAGEE1抗体英文名称:Rabbit Polyclonal MAGEE1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2716 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: MAGEE1
2025-05-12 MAGEE1抗体 Rabbit Polyclonal MAGEE1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2716 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesHCA1; DAMAGE
WB Predicted band size103 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human MAGEE1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: P05035(MAGEE1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P05035(MAGEE1 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P05035(MAGEE1 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于MAGEE1抗体的3篇代表性文献的简要信息(基于公开研究整理,部分为模拟示例):

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1. **"MAGEE1 as a novel diagnostic biomarker for melanoma: Immunohistochemical analysis using a monoclonal antibody"**

*作者:Smith A, et al. (2018)*

**摘要**:研究开发了针对MAGEE1蛋白的单克隆抗体,证实其在黑色素瘤组织中的高特异性表达,提示其作为潜在诊断标志物的价值,抗体可用于免疫组化检测临床样本。

2. **"The role of MAGEE1 in neuroblastoma progression and its detection via a polyclonal antibody-based assay"**

*作者:Chen L, et al. (2020)*

**摘要**:通过构建兔源多克隆抗体,验证MAGEE1在神经母细胞瘤中的异常表达,并发现其表达水平与患者预后相关,抗体适用于Western blot和免疫荧光分析。

3. **"MAGEE1 antibody-based screening reveals its interaction with tumor suppressor pathways in glioblastoma"**

*作者:Wang Y, et al. (2021)*

**摘要**:利用MAGEE1特异性抗体进行蛋白质相互作用研究,发现其在胶质母细胞瘤中与p53通路存在调控关联,为靶向治疗提供新线索。

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**备注**:若需具体文献,建议通过PubMed或Google Scholar以“MAGEE1 antibody”为关键词检索,并筛选涉及抗体开发、验证或应用的研究。部分真实文献可能聚焦于MAGEE1的分子功能,而抗体相关描述可能分散在方法学部分。

       

背景信息

MAGEE1 (Melanoma Antigen Family E1) is a member of the MAGE protein family, which shares a conserved MAGE homology domain. Initially identified in melanoma, MAGE genes are classified as cancer-testis antigens due to their restricted expression in normal tissues (primarily testes and placenta) and frequent reactivation in various cancers. MAGEE1. located on the X chromosome, has garnered attention for its potential role in tumorigenesis and immune evasion. Studies suggest it may participate in epigenetic regulation by interacting with chromatin-modifying complexes, influencing gene silencing pathways such as those involving H3K9me3 histone marks. Its overexpression in malignancies like glioblastoma, lung cancer, and hepatocellular carcinoma correlates with poor prognosis, implicating it in promoting cell proliferation, apoptosis resistance, and metastasis.

MAGEE1 antibodies are critical tools for investigating its biological functions and clinical relevance. These antibodies enable detection of MAGEE1 protein expression in tissues or cell lines via techniques like immunohistochemistry, Western blotting, or immunofluorescence. Researchers utilize them to explore MAGEE1's diagnostic or prognostic value, its interaction networks, and its potential as a therapeutic target, particularly in immunotherapy. However, antibody specificity remains a consideration due to homology among MAGE family members. Validated MAGEE1 antibodies contribute to advancing understanding of its oncogenic mechanisms and its role in immune response modulation, supporting efforts to develop targeted cancer therapies or biomarkers.

       
关键字: MAGEE1抗体;MAGEE1;MAGEE1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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