MFF抗体

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P05048(MFF Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P05048(MFF Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

MFF (Mitochondrial Fission Factor) antibodies are essential tools for studying mitochondrial dynamics, particularly fission processes critical to cellular health. MFF is a key membrane-bound adaptor protein that recruits the GTPase Drp1 (Dynamin-related protein 1) to mitochondrial and peroxisomal membranes, triggering membrane scission. Dysregulation of MFF-mediated fission is linked to neurodegenerative diseases, metabolic disorders, and cancer, as it impacts organelle function, energy metabolism, and apoptosis.

MFF antibodies enable researchers to detect MFF expression levels, localization, and interactions via techniques like Western blot, immunofluorescence, and immunoprecipitation. They are widely used in studies exploring cellular stress responses, mitophagy, and disease mechanisms. For instance, reduced MFF levels correlate with fragmented mitochondria in Parkinson’s models, while overexpression is observed in certain cancers. Commercial MFF antibodies are typically validated for specificity across human, mouse, and rat samples. Ongoing research focuses on how MFF post-translational modifications (e.g., phosphorylation) regulate its activity, offering therapeutic insights. These antibodies thus bridge fundamental biology and translational studies targeting mitochondrial dysfunction.