NOX3抗体

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     Western blot analysis of MRP8 expression in  HL-60 cell lysate.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human breast cancer, using MRP8 Antibody.    

  
  

NOX3 (NADPH oxidase 3) is a member of the NADPH oxidase family, which plays a critical role in generating reactive oxygen species (ROS) by transferring electrons across biological membranes. Discovered in 2001. NOX3 is primarily expressed in inner ear tissues, particularly the vestibular and cochlear systems, where it contributes to physiological processes such as otoconia formation and hearing function. Unlike other NOX isoforms (e.g., NOX1. NOX2. NOX4), NOX3 exhibits restricted tissue distribution and requires specific regulatory subunits (e.g., NOXO1. NOXA1) for activation. Its dysregulation has been implicated in hearing loss, oxidative stress-related disorders, and neurodegenerative conditions.

NOX3 antibodies are essential tools for studying its expression, localization, and functional roles. These antibodies target specific epitopes within NOX3's structural domains, such as its transmembrane or intracellular regions. Researchers utilize them in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate NOX3's involvement in pathologies like noise-induced hearing loss, age-related hearing decline, and cisplatin-induced ototoxicity. Additionally, NOX3 antibodies aid in exploring its interaction with signaling pathways, including those linked to inflammation and apoptosis. Recent studies also highlight NOX3's potential role in cancer progression, particularly in tumors with oxidative stress-driven mechanisms. The development of selective NOX3 antibodies remains challenging due to structural similarities among NADPH oxidase isoforms, emphasizing the need for rigorous validation to ensure specificity in experimental models.