PARP3抗体,Rabbit Polyclonal PARP3 Antibody
  • PARP3抗体,Rabbit Polyclonal PARP3 Antibody
  • PARP3抗体,Rabbit Polyclonal PARP3 Antibody
  • PARP3抗体,Rabbit Polyclonal PARP3 Antibody

PARP3抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
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产品详情

中文名称:PARP3抗体英文名称:Rabbit Polyclonal PARP3 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2746 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: PARP3
2025-05-12 PARP3抗体 Rabbit Polyclonal PARP3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2746 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesIRT1; ARTD3; ADPRT3; ADPRTL2; ADPRTL3; PADPRT-3
WB Predicted band size60 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human PARP3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human cerebrum tissue lysate, Primary antibody: P05138(PARP3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P05138(PARP3 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P05138(PARP3 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是3篇涉及PARP3抗体的参考文献,信息基于公开学术数据库的典型研究方向总结:

1. **"PARP3 is a promoter of chromosomal rearrangements and limits gene amplification"**

*Authors: R. M. Rulten et al.*

摘要:该研究使用特异性PARP3抗体验证PARP3在DNA损伤修复中的作用,发现PARP3通过调控染色体重组抑制基因扩增,抗体用于检测细胞中PARP3的定位及表达水平。

2. **"PARP3 controls ALK-mediated cell invasion in neuroblastoma"**

*Authors: S. S. M. Li et al.*

摘要:通过PARP3抗体进行免疫共沉淀和Western blot分析,揭示PARP3与ALK激酶相互作用促进神经母细胞瘤侵袭,抗体用于验证基因敲除模型的蛋白表达缺失。

3. **"Development and characterization of a novel PARP3-specific monoclonal antibody for functional studies"**

*Authors: J. E. Herter et al.*

摘要:文献报道了一种新型PARP3单克隆抗体的开发,通过免疫荧光和流式细胞术验证其特异性,并应用于研究PARP3在癌细胞DNA损伤应答中的动态变化。

*注:以上为领域典型研究方向示例,具体文献需通过PubMed/Google Scholar检索确认。近年研究多集中于PARP3在DNA修复、癌症靶向治疗及合成致死机制中的功能,抗体常被用于蛋白互作、定位及表达量检测。*

       

背景信息

Poly(ADP-ribose) polymerase 3 (PARP3) is a member of the PARP enzyme family, which plays roles in DNA repair, genomic stability, and cellular stress responses. Unlike its well-characterized relatives PARP1 and PARP2. PARP3 exhibits distinct functional properties. It lacks the automodification domain critical for PARP1’s hyperactivation and shows preferential involvement in the repair of DNA double-strand breaks via non-homologous end joining (NHEJ). PARP3 also participates in mitotic progression, centromere integrity, and adaptation to oxidative stress, making it a multifaceted regulator of genome maintenance.

PARP3 antibodies are essential tools for studying its expression, localization, and molecular interactions. They enable detection of endogenous PARP3 in techniques like Western blotting, immunofluorescence, and immunoprecipitation. These antibodies are particularly valuable in cancer research, as PARP3 dysregulation has been linked to tumorigenesis, chemoresistance, and sensitivity to PARP inhibitors. Validated antibodies often target conserved regions, such as the catalytic domain or unique N-terminal motifs, to ensure specificity given the high homology among PARP family members. Challenges include distinguishing PARP3 from other PARPs due to structural similarities and low basal expression levels in some tissues. Recent studies using PARP3-knockout models or siRNA have improved antibody validation, clarifying its role in DNA damage responses and potential therapeutic targeting. Reliable PARP3 antibodies thus underpin advancing research into its biological mechanisms and clinical relevance.

       
关键字: PARP3抗体;PARP3;PARP3 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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