TRIM3抗体,Rabbit Polyclonal TRIM3 Antibody
  • TRIM3抗体,Rabbit Polyclonal TRIM3 Antibody
  • TRIM3抗体,Rabbit Polyclonal TRIM3 Antibody
  • TRIM3抗体,Rabbit Polyclonal TRIM3 Antibody

TRIM3抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
QQ交谈 微信洽谈

产品详情

中文名称:TRIM3抗体英文名称:Rabbit Polyclonal TRIM3 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2776 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: TRIM3
2025-05-12 TRIM3抗体 Rabbit Polyclonal TRIM3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2776 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesBERP; HAC1; RNF22; RNF97
WB Predicted band size81 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human TRIM3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse brain tissue, human fetal brain tissue, Primary antibody: P05232(TRIM3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P05232(TRIM3 Antibody) at dilution 1/45. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P05232(TRIM3 Antibody) at dilution 1/45. (Original magnification: ×200)    


           

参考文献

以下是3篇涉及TRIM3抗体的代表性文献摘要(人工整理,非真实文献,供参考):

1. **文献名称**:TRIM3 regulates neuronal excitability through ubiquitination of potassium channels

**作者**:Lee et al. (2018)

**摘要**:研究利用TRIM3特异性抗体,发现TRIM3通过泛素化修饰调控钾离子通道蛋白稳定性,影响神经元电活动,可能与癫痫病理相关。

2. **文献名称**:TRIM3 suppresses tumor metastasis by targeting β-catenin in hepatocellular carcinoma

**作者**:Zhang et al. (2020)

**摘要**:通过TRIM3抗体进行免疫共沉淀实验,揭示TRIM3通过促进β-catenin降解抑制肝癌细胞侵袭转移,其表达水平与患者预后正相关。

3. **文献名称**:TRIM3 modulates autophagosome-lysosome fusion via binding LC3

**作者**:Wang et al. (2021)

**摘要**:研究使用TRIM3抗体进行免疫荧光共定位,证明TRIM3通过结合自噬标志蛋白LC3调控自噬体-溶酶体融合过程,影响细胞稳态。

4. **文献名称**:Developmental expression of TRIM3 in mouse brain revealed by antibody-based staining

**作者**:Chen et al. (2019)

**摘要**:通过TRIM3抗体的免疫组化分析,发现TRIM3在小鼠胚胎大脑皮层神经元中高表达,提示其在神经发育中的潜在作用。

注:以上文献信息为示例性质,实际文献需通过PubMed或Web of Science检索确认。

       

背景信息

The TRIM3 antibody targets Tripartite Motif-containing protein 3 (TRIM3), a member of the TRIM family characterized by conserved RING, B-box, and coiled-coil domains. TRIM3 plays diverse roles in cellular processes, including protein ubiquitination, intracellular signaling, and vesicular trafficking. It functions as an E3 ubiquitin ligase, regulating substrate degradation via the ubiquitin-proteasome system. TRIM3 is highly expressed in the brain, where it influences neuronal development, synaptic plasticity, and autophagy. Dysregulation of TRIM3 has been implicated in neurological disorders, such as Alzheimer’s disease, and cancers, including gliomas and hepatocellular carcinoma, where it may act as a tumor suppressor or promoter depending on context.

TRIM3 antibodies are essential tools for detecting TRIM3 expression and localization in tissues or cell lines via techniques like Western blotting, immunohistochemistry, and immunofluorescence. They aid in studying TRIM3's interaction partners, post-translational modifications, and mechanistic roles in disease pathways. Recent studies highlight TRIM3's involvement in regulating apoptosis, cell cycle progression, and immune responses, underscoring its therapeutic potential. Validated antibodies help clarify its dual roles in different cancers and neurological conditions, making it a focus for biomarker discovery and targeted therapy development.

       
关键字: TRIM3抗体;TRIM3;TRIM3 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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