PRAF2抗体,Rabbit Polyclonal PRAF2 Antibody
  • PRAF2抗体,Rabbit Polyclonal PRAF2 Antibody
  • PRAF2抗体,Rabbit Polyclonal PRAF2 Antibody
  • PRAF2抗体,Rabbit Polyclonal PRAF2 Antibody

PRAF2抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
QQ交谈 微信洽谈

产品详情

中文名称:PRAF2抗体英文名称:Rabbit Polyclonal PRAF2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2779 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: PRAF2
2025-05-12 PRAF2抗体 Rabbit Polyclonal PRAF2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2779 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesJM4
WB Predicted band size19 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human PRAF2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Human fetal brain tissue, A549 cells, hela cells, 293T cells, Primary antibody: P05240(PRAF2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P05240(PRAF2 Antibody) at dilution 1/35. (Original magnification: ×200)    


           

参考文献

以下是关于PRAF2抗体的3篇参考文献示例(注:以下内容为模拟示例,非真实文献):

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1. **文献名称**: *PRAF2 modulates apoptosis signaling through interaction with Bcl-2 family proteins*

**作者**: Li X, Zhang Y, et al.

**摘要**: 本研究利用PRAF2特异性抗体,通过免疫共沉淀和Western blot技术,揭示了PRAF2与Bcl-2家族蛋白的相互作用机制,证明其在调控线粒体途径细胞凋亡中的作用,为癌症治疗靶点研究提供依据。

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2. **文献名称**: *Overexpression of PRAF2 in hepatocellular carcinoma and its clinical significance*

**作者**: Wang H, Chen J, et al.

**摘要**: 通过免疫组化(使用PRAF2多克隆抗体)分析肝癌组织样本,发现PRAF2在肝癌中高表达且与患者预后不良相关,提示其可能作为肝癌诊断的潜在生物标志物。

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3. **文献名称**: *Development and validation of a novel monoclonal antibody against human PRAF2 for flow cytometry applications*

**作者**: Smith KA, Brown R, et al.

**摘要**: 本文报道了一种针对人源PRAF2的新型单克隆抗体的开发与验证,该抗体在流式细胞术中表现出高特异性和灵敏度,成功应用于白血病细胞系的表面蛋白定量分析。

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如需真实文献,建议通过PubMed或Google Scholar以关键词“PRAF2 antibody”、“PRAF2 function”进行检索,并筛选近五年内与您研究领域相关的论文。

       

背景信息

The PRAF2 (Prenylated Rab Acceptor 1 Family Member 2) protein, also known as RAPH1. is a member of the PRAF family involved in intracellular vesicular trafficking and membrane dynamics. It interacts with prenylated Rab GTPases, facilitating their proper subcellular localization and function in secretory pathways. PRAF2 is predominantly localized to the Golgi apparatus and endoplasmic reticulum, playing roles in maintaining organelle integrity and regulating protein transport. Studies suggest its involvement in apoptosis, where it may act as a pro-apoptotic factor by interacting with Bcl-2 family proteins or modulating mitochondrial pathways.

Aberrant PRAF2 expression has been linked to human diseases, particularly cancers. Overexpression is observed in certain tumors, correlating with poor prognosis, tumor progression, and metastasis, potentially through pathways affecting cell proliferation, migration, or chemoresistance. Conversely, reduced expression has been implicated in neurodevelopmental disorders, highlighting its tissue-specific roles.

PRAF2 antibodies are essential tools for detecting protein expression, localization, and interaction partners in research. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in the exploration of PRAF2’s biological functions and pathological mechanisms. Commercial antibodies are typically generated using recombinant protein fragments or synthetic peptides, with validation across experimental models. Ongoing research focuses on clarifying PRAF2’s dual roles in cancer and neurological processes, positioning it as a potential diagnostic marker or therapeutic target.

       
关键字: PRAF2抗体;PRAF2;PRAF2 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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