SYCP1抗体

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P05256(SYCP1 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

The SYCP1 antibody targets the Synaptonemal Complex Protein 1 (SYCP1), a key component of the synaptonemal complex (SC) essential for meiosis in eukaryotic cells. SYCP1 is primarily expressed in germ cells during prophase I of meiosis, where it mediates the pairing, alignment, and recombination of homologous chromosomes. Structurally, SYCP1 forms the transverse filaments of the SC, bridging the axes of paired chromosomes to ensure proper synapsis and genetic exchange. Dysregulation of SYCP1 is linked to infertility, gametogenesis defects, and chromosomal abnormalities.

SYCP1 antibodies are widely used in reproductive biology research to study meiotic processes, gamete development, and infertility mechanisms. These antibodies enable visualization of SC assembly and dynamics via techniques like immunofluorescence (IF), immunohistochemistry (IHC), and Western blotting (WB). They are typically raised in hosts such as rabbits or mice using recombinant SYCP1 protein fragments or peptide sequences. Validation often includes testing on knockout models or tissues with known SYCP1 expression patterns to confirm specificity.

Clinically, SYCP1 antibodies serve as diagnostic tools for investigating genetic causes of infertility or meiotic errors. Their application extends to studying model organisms (e.g., mice, zebrafish) to unravel conserved meiotic mechanisms. As research advances, SYCP1 antibodies remain critical for understanding chromosomal synapsis, DNA repair, and their roles in reproductive health and disease.