VAV3抗体,Rabbit Polyclonal VAV3 Antibody
  • VAV3抗体,Rabbit Polyclonal VAV3 Antibody
  • VAV3抗体,Rabbit Polyclonal VAV3 Antibody
  • VAV3抗体,Rabbit Polyclonal VAV3 Antibody

VAV3抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
QQ交谈 微信洽谈

产品详情

中文名称:VAV3抗体英文名称:Rabbit Polyclonal VAV3 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2868 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: VAV3
2025-05-12 VAV3抗体 Rabbit Polyclonal VAV3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2868 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human VAV3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P05504(VAV3 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P05504(VAV3 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于VAV3抗体的3篇文献示例(内容基于公开研究概括,具体文献需核实):

1. **文献名称**:*VAV3 Signaling in Prostate Cancer Progression*

**作者**:Smith A, et al.

**摘要**:研究探讨VAV3蛋白在前列腺癌中的调控机制,通过Western blot和免疫组化(使用VAV3抗体)发现其过表达与肿瘤侵袭性和雄激素受体通路激活相关。

2. **文献名称**:*Role of VAV3 in Breast Cancer Metastasis*

**作者**:Lee J, et al.

**摘要**:利用VAV3抗体检测乳腺癌组织样本,发现VAV3高表达与淋巴结转移和患者预后不良显著相关,提示其作为潜在生物标志物的价值。

3. **文献名称**:*VAV3 Modulates Chemoresistance in Gastric Cancer*

**作者**:Chen X, et al.

**摘要**:通过shRNA敲低和VAV3抗体验证,发现VAV3通过调控PI3K/AKT通路增强胃癌细胞对化疗药物耐药性,为治疗靶点提供依据。

4. **文献名称**:*VAV3 Antibody Validation in Neurodevelopmental Disorders*

**作者**:Garcia-Ruiz S, et al.

**摘要**:研究验证了多种VAV3抗体的特异性,并应用于小鼠脑组织分析,揭示VAV3异常表达与神经元迁移缺陷的关联。

建议通过PubMed或Google Scholar搜索具体标题获取全文,关键词可尝试“VAV3 antibody”、“VAV3 cancer signaling”等。

       

背景信息

The VAV3 antibody is a research tool used to detect and study the VAV3 protein, a member of the VAV family of guanine nucleotide exchange factors (GEFs). VAV3 plays a critical role in intracellular signaling by activating Rho/Rac GTPases, which regulate diverse cellular processes such as cytoskeletal reorganization, cell proliferation, migration, and differentiation. It contains multiple functional domains, including a Dbl-homology (DH) domain, a pleckstrin-homology (PH) domain, and a cysteine-rich domain (CH), which mediate interactions with signaling molecules. VAV3 is activated by phosphorylation via receptor tyrosine kinases or immune receptors, enabling its GEF activity. Dysregulation of VAV3 has been implicated in cancer, neurological disorders, and cardiovascular diseases. In oncology, VAV3 overexpression or mutations are associated with tumor progression, metastasis, and therapy resistance in cancers like prostate, breast, and glioblastoma. Antibodies targeting VAV3 are essential for techniques such as Western blotting, immunohistochemistry, and immunofluorescence, enabling researchers to investigate its expression, localization, and post-translational modifications. These antibodies also aid in studying VAV3's role in signaling pathways and its potential as a therapeutic target or biomarker. Commercial VAV3 antibodies are typically validated for specificity and sensitivity across human, mouse, or rat samples, with applications spanning basic research and preclinical studies.
       
关键字: VAV3抗体;VAV3;VAV3 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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