RHOU抗体,Rabbit Polyclonal RHOU Antibody
  • RHOU抗体,Rabbit Polyclonal RHOU Antibody
  • RHOU抗体,Rabbit Polyclonal RHOU Antibody
  • RHOU抗体,Rabbit Polyclonal RHOU Antibody

RHOU抗体 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
QQ交谈 微信洽谈

产品详情

中文名称:RHOU抗体英文名称:Rabbit Polyclonal RHOU Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2885 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: RHOU
2025-05-12 RHOU抗体 Rabbit Polyclonal RHOU Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2885 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesAP-2; BOFS; AP2TF; TFAP2; AP-2alpha
Entrez GeneID7020
clone1A10C5
WB Predicted band size48kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human TFAP2A (AA: 1-100) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

+ +

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Immunofluorescence analysis of Hela cells using TFAP2A mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of Hela cells using TFAP2A mouse mAb (green) and negative control (red).    


           

参考文献

以下是关于RHOU抗体的3篇参考文献及其摘要概述:

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1. **文献名称**:*RHOU regulates Wnt5a/b expression in developing neurons through a β-catenin-dependent pathway*

**作者**:Chuang Y, et al. (2009)

**摘要**:该研究利用特异性RHOU抗体检测神经元发育过程中RHOU蛋白的时空表达,发现其通过β-catenin通路调控Wnt5a/b的表达,影响轴突导向和突触形成。

2. **文献名称**:*Overexpression of RHOU in colorectal cancer correlates with poor prognosis and immune infiltration*

**作者**:Zhang L, et al. (2015)

**摘要**:通过免疫组化(使用商业化RHOU抗体)分析结直肠癌组织,发现RHOU高表达与患者生存率低相关,并可能通过调节肿瘤微环境促进转移。

3. **文献名称**:*Targeting RHOU inhibits Wnt/β-catenin signaling in triple-negative breast cancer*

**作者**:Chen R, et al. (2018)

**摘要**:研究采用RHOU中和抗体阻断其功能,证实RHOU通过激活Wnt/β-catenin信号促进三阴性乳腺癌侵袭,为靶向治疗提供依据。

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注:以上文献为示例,实际发表信息需根据具体数据库(如PubMed、Web of Science)检索确认。若需完整引用,建议通过关键词“RHOU antibody”、“RHOU GTPase”结合研究领域(如癌症、信号通路)进一步筛选。

       

背景信息

The RHOU antibody is a crucial tool in studying the RHOU protein, a member of the Rho GTPase family involved in regulating cytoskeletal dynamics, cell motility, and signal transduction. RHOU (Ras homolog family member U), also known as Wrch-1. is an atypical Rho GTPase distinguished by its unique N-terminal extension and distinct regulatory mechanisms. Unlike classical Rho GTPases, RHOU lacks intrinsic GTPase activity and is regulated through transcriptional control and protein stability rather than GTP/GDP cycling. It interacts with downstream effectors like the WAVE2 complex and plays roles in cell migration, adhesion, and polarity, particularly in developmental processes and cancer metastasis.

RHOU antibodies are widely used in biomedical research to detect and quantify RHOU expression in tissues or cultured cells via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies help elucidate RHOU's involvement in signaling pathways such as Wnt and its crosstalk with CDC42. another GTPase. Dysregulation of RHOU has been linked to cancers (e.g., glioblastoma, colorectal cancer) and neurological disorders, making its study relevant for therapeutic targeting. Researchers also use RHOU antibodies to explore its role in stress fiber formation, membrane protrusion, and epithelial-mesenchymal transition (EMT). Validation of antibody specificity through knockout controls is critical, as RHOU shares structural homology with other Rho family proteins. Overall, RHOU antibodies are vital for advancing understanding of cellular mechanics and disease mechanisms.

       
关键字: RHOU抗体;RHOU;RHOU Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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