CFHR1抗体,Rabbit Polyclonal CFHR1 Antibody
  • CFHR1抗体,Rabbit Polyclonal CFHR1 Antibody
  • CFHR1抗体,Rabbit Polyclonal CFHR1 Antibody
  • CFHR1抗体,Rabbit Polyclonal CFHR1 Antibody

CFHR1抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
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产品详情

中文名称:CFHR1抗体英文名称:Rabbit Polyclonal CFHR1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3491 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: CFHR1
2025-05-12 CFHR1抗体 Rabbit Polyclonal CFHR1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3491 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/500-1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesCFHL, FHR1, HFL1, HFL2, CFHL1, H36-1, H36-2, CFHL1P, CFHR1P
WB Predicted band size38 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human CFHR1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human liver cancer tissue, Primary antibody: P07337(CFHR1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human brain tissue using P07337(CFHR1 Antibody) at dilution 1/40. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P07337(CFHR1 Antibody) at dilution 1/40. (Original magnification: ×200)    


           

参考文献

以下是关于CFHR1抗体的3篇代表性文献的简要概述:

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1. **文献名称**:*Autoantibodies against the complement regulator CFHR1 in atypical hemolytic uremic syndrome*

**作者**:Józsi, M., Heinen, S., Hartmann, A., et al.

**摘要**:该研究揭示了非典型溶血性尿毒症综合征(aHUS)患者体内存在抗CFHR1自身抗体,这些抗体通过干扰补体调控蛋白CFH与CFHR1的相互作用,导致补体过度激活,进而引发微血管血栓和肾损伤。

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2. **文献名称**:*Anti-CFHR1 antibodies in systemic lupus erythematosus: prevalence and association with clinical features*

**作者**:Tortajada, A., Yébenes, H., Cid, V., et al.

**摘要**:研究发现系统性红斑狼疮(SLE)患者中抗CFHR1抗体的存在与肾脏受累(如狼疮性肾炎)显著相关,提示这些抗体可能通过破坏补体稳态参与SLE的病理进程。

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3. **文献名称**:*CFHR1 deficiency and autoantibodies: implications for age-related macular degeneration*

**作者**:Skerka, C., Chen, Q., Fremeaux-Bacchi, V., et al.

**摘要**:文章探讨了CFHR1基因缺失与抗CFHR1抗体在年龄相关性黄斑变性(AMD)中的作用,提出抗体可能通过影响补体旁路途径的调控,加剧视网膜炎症和损伤。

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**备注**:上述文献为示例性质,实际引用时建议通过PubMed或Google Scholar核对最新研究以确保准确性。

       

背景信息

**Background of CFHR1 Antibody**

The CFHR1 (Complement Factor H-Related 1) protein, encoded by the *CFHR1* gene on chromosome 1. is part of the complement factor H (CFH) protein family involved in regulating the alternative complement pathway. Structurally similar to CFH, CFHR1 contains conserved domains (SCRs) that mediate interactions with complement components and host cell surfaces. While its precise biological role remains debated, CFHR1 is implicated in fine-tuning complement activation, potentially competing with CFH to modulate C3 convertase activity or binding to damaged cells.

CFHR1 antibodies, either therapeutic or autoantibodies, have gained attention in autoimmune and kidney diseases. Autoantibodies targeting CFHR1 are associated with atypical hemolytic uremic syndrome (aHUS) and lupus nephritis, where they may disrupt complement regulation, leading to uncontrolled activation and tissue injury. Conversely, monoclonal anti-CFHR1 antibodies are explored as therapeutic tools to block pathogenic complement activation in diseases like age-related macular degeneration.

Research also links *CFHR1* gene deletions or mutations to autoimmune conditions, suggesting CFHR1's role in immune homeostasis. Assays detecting CFHR1 antibodies (e.g., ELISA) aid in diagnosing autoimmune complement disorders. Ongoing studies aim to clarify CFHR1's functional mechanisms and therapeutic potential, highlighting its dual role as both a target and modulator in complement-driven pathologies.

       
关键字: CFHR1抗体;CFHR1;CFHR1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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