AMACR抗体,Rabbit Polyclonal AMACR Antibody
  • AMACR抗体,Rabbit Polyclonal AMACR Antibody
  • AMACR抗体,Rabbit Polyclonal AMACR Antibody
  • AMACR抗体,Rabbit Polyclonal AMACR Antibody

AMACR抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
QQ交谈 微信洽谈

产品详情

中文名称:AMACR抗体英文名称:Rabbit Polyclonal AMACR Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3365 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: AMACR
2025-05-12 AMACR抗体 Rabbit Polyclonal AMACR Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3365 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesRM; RACE; CBAS4; AMACRD
WB Predicted band size42 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human AMACR
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Jurkat cells, Primary antibody: P07073(AMACR Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07073(AMACR Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P07073(AMACR Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于AMACR(α-甲基酰基辅酶A消旋酶)抗体的3篇参考文献,按文献名称、作者和摘要内容概括整理:

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1. **文献名称**:*α-Methylacyl-CoA Racemase: A New Molecular Marker for Prostate Cancer*

**作者**:Jiang Z, Woda BA, Rock KL, et al.

**摘要**:该研究首次提出AMACR作为前列腺癌特异性生物标志物,通过免疫组化分析显示其在癌组织中高表达,而在正常或良性前列腺组织中表达缺失,提示AMACR抗体在病理诊断中的潜在价值。

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2. **文献名称**:*Role of α-Methylacyl-CoA Racemase in the Differential Diagnosis of Prostate Cancer*

**作者**:Rubin MA, Zhou M, Dhanasekaran SM, et al.

**摘要**:研究验证了AMACR抗体在鉴别前列腺癌与良性组织中的高敏感性和特异性,结合基底细胞标记物(如p63)可提高病理诊断准确性,推动其成为临床常规检测指标。

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3. **文献名称**:*AMACR Expression in Prostatic Adenocarcinoma and Hepatocellular Carcinoma: A Comparative Study*

**作者**:Zhou M, Chinnaiyan AM, Kleer CG, et al.

**摘要**:通过比较AMACR抗体在不同癌症中的表达,发现其在前列腺癌和肝细胞癌中均显著上调,但与其他肿瘤标志物(如HepPar1)联合使用可提升鉴别诊断的可靠性。

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**备注**:以上文献均发表于2000年代初,为AMACR抗体的早期关键研究,推动了其在肿瘤病理学(尤其是前列腺癌)中的应用。如需具体年份或期刊信息,可进一步补充检索PubMed或Web of Science数据库。

       

背景信息

Alpha-methylacyl-CoA racemase (AMACR), also known as P504S, is a mitochondrial and peroxisomal enzyme involved in the β-oxidation of branched-chain fatty acids and bile acid intermediates. Its role in lipid metabolism and association with cancer was first identified in the early 2000s. AMACR gained prominence as a biomarker when studies revealed its overexpression in prostate cancer cells compared to benign prostatic tissue. This discovery positioned AMACR antibodies as valuable tools in diagnostic pathology.

In clinical practice, AMACR immunohistochemical staining is widely used to distinguish prostate adenocarcinoma from benign mimics, particularly in small biopsy specimens. Its utility extends to confirming malignancy in ambiguous glandular proliferations. AMACR is often combined with basal cell markers (e.g., p63. 34βE12) to improve diagnostic accuracy. Beyond prostate cancer, AMACR expression has been observed in other malignancies, including colorectal carcinoma, renal cell carcinoma, and some hepatocellular carcinomas, though with variable specificity.

While highly sensitive for prostate cancer (positive in ~80-95% of cases), AMACR's limitations include occasional negativity in certain subtypes (e.g., foamy or pseudohyperplastic variants) and focal positivity in benign conditions like nephrogenic adenoma. Despite these caveats, AMACR remains a cornerstone in modern pathology workflows, exemplifying the translation of molecular discoveries into practical diagnostic applications.

       
关键字: AMACR抗体;AMACR;AMACR Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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