ATP4B抗体

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse pancreas tissue, Primary antibody: P07125(ATP4B Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07125(ATP4B Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P07125(ATP4B Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The ATP4B antibody targets the beta subunit of the gastric H+/K+ ATPase, a proton pump critical for acid secretion in parietal cells of the stomach. This enzyme exchanges cytoplasmic H+ ions for luminal K+ ions, generating the highly acidic gastric environment necessary for digestion. ATP4B antibodies are primarily associated with autoimmune gastritis, a chronic inflammatory condition where the immune system mistakenly attacks gastric parietal cells. Their presence often correlates with the destruction of acid-producing cells, leading to hypochlorhydria (reduced stomach acid) and impaired absorption of nutrients like vitamin B12. which may progress to pernicious anemia.

These antibodies are detected in approximately 50–70% of autoimmune gastritis cases and are frequently observed alongside ATP4A (alpha subunit) antibodies. Clinically, ATP4B antibody testing aids in diagnosing autoimmune gastritis, distinguishing it from other forms of gastritis or anemia. They are also linked to autoimmune polyendocrine syndromes, coexisting with other autoantibodies (e.g., thyroid or pancreatic islet cell antibodies). Detection methods include immunoassays (ELISA, Western blot) or indirect immunofluorescence. While not exclusive to autoimmune gastritis, their presence supports a diagnosis when combined with clinical symptoms, histopathology, and biomarkers like elevated gastrin or low pepsinogen levels. Research continues to explore their pathogenic role and utility in monitoring disease progression.