CLEC7A抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 231 cell lysate, Primary antibody: P07175(CLEC7A Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 90 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P07175(CLEC7A Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P07175(CLEC7A Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

CLEC7A (C-type lectin domain containing 7A), also known as Dectin-1. is a transmembrane C-type lectin receptor primarily expressed on myeloid cells, including macrophages, dendritic cells, and neutrophils. It plays a critical role in innate immunity by recognizing β-glucans, polysaccharide components found in fungal cell walls, and certain bacteria. Upon ligand binding, CLEC7A activates intracellular signaling pathways through its immunoreceptor tyrosine-based activation motif (ITAM)-like motif, recruiting Syk kinase to trigger downstream responses such as phagocytosis, reactive oxygen species production, and cytokine release (e.g., TNF-α, IL-6). This receptor bridges microbial recognition to adaptive immunity by modulating T-cell responses.

CLEC7A antibodies are essential tools for studying its expression, function, and signaling mechanisms. They are widely used in applications like flow cytometry, immunofluorescence, and Western blotting to investigate CLEC7A's role in antifungal defense, inflammatory diseases, and cancer. Dysregulation of CLEC7A has been linked to autoimmune disorders (e.g., rheumatoid arthritis), chronic inflammation, and tumor progression, making it a potential therapeutic target. Antibodies targeting CLEC7A also contribute to developing immunotherapies, such as antibody-drug conjugates or checkpoint inhibitors. Research continues to explore its dual role in host protection and pathological inflammation, emphasizing its importance in both infectious and non-infectious diseases.